Evidence map›Paper›PMID 38961984›Full record

ArticleHeliyon2024

Hearing loss is not associated with risk of Parkinson's disease: A Mendelian randomization study.

Pingping Ning, Xin Mu, Xingzhi Guo, Rui Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pingping NingDepartment of Geriatric Neurology, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.
Xin MuDepartment of Neurology, Chengdu First People's Hospital, No. 18 Wanxiang North Road, Chengdu, 610041, China.
Xingzhi GuoDepartment of Geriatric Neurology, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.
Rui LiDepartment of Geriatric Neurology, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: A few observational studies have indicated that Parkinson's disease (PD) risk may be higher in those with hearing loss, but the two's causal relationship is yet unknown. Using Mendelian randomization (MR) methods, this study sought to explore the causal link between hearing loss and the risk of PD. Methods: We identified single nucleotide polymorphisms (SNPs) linked to hearing loss ( Results: Twenty-two SNPs with genome-wide significance linked to hearing loss were used as instrumental factors. In the discovery dataset, we failed to detect a causal relationship between hearing loss and PD (OR = 1.297; 95 % CI = 0.420-4.007; Conclusion: In those of European heritage, our investigation revealed no causal link between hearing loss and PD risk.

Indexed as

Genome-wide association studyHearing lossMendelian randomization studyParkinson's disease

Identifiers

PMID38961984
PMCPMC11219492

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.