Evidence map›Paper›PMID 38961916›Full record

ArticleHeliyon2024

Sexual health and testosterone concentration in male lymphoma survivors: A systematic review.

Signe Micas Pedersen, Ditte Stampe Hersby, Mary Jarden, Torsten Holm Nielsen, Anne Ortved Gang, Christian Bjørn Poulsen, Peter de Nully Brown, Niels Jørgensen, Claus Larsen Feltoft, Lars Møller Pedersen

Abstract read
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Signe Micas PedersenDepartment of Hematology, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100, KBH Ø, Denmark.
Ditte Stampe HersbyDepartment of Hematology, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100, KBH Ø, Denmark.
Mary JardenDepartment of Hematology, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100, KBH Ø, Denmark.
Torsten Holm NielsenDepartment of Hematology, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100, KBH Ø, Denmark.
Anne Ortved GangDepartment of Hematology, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100, KBH Ø, Denmark.
Christian Bjørn PoulsenDepartment of Hematology, Zealand University Hospital, Vestermarksvej 15, 4000, Roskilde, Denmark.
Peter de Nully BrownDepartment of Hematology, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100, KBH Ø, Denmark.
Niels JørgensenDepartment of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100, KBH Ø, Denmark.
Claus Larsen FeltoftDepartment of Endocrinology, Copenhagen University Hospital - Herlev and Gentofte, Borgmester Ib Juuls Vej 1, 2730, Herlev, Denmark.
Lars Møller PedersenDepartment of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 KBH N, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advancements in lymphoma treatment have increased the number of long-term survivors who may experience late effects such as impaired sexual function and testosterone deficiency. The aim of this review was to determine the prevalence of testosterone deficiency and sexual dysfunction among male lymphoma survivors; and associations between the two. A systematic search identified 20 articles for inclusion. The prevalence of low total testosterone was 0%-50 %, with mean values within reference levels, and for luteinizing hormone above reference levels in 0%-80 %. Four studies included SHBG and free testosterone, with mixed results. Compromised sexual health was found in 23%-61 %. Overall, total testosterone and sexual health were associated. The risk of bias (ROBINS-E and RoB 2) was high/very high, leading to low/very low overall confidence in the bulk of evidence (GRADE). Longitudinal studies evaluating biologically active testosterone and sexual health are needed, to develop evidence based standard procedures for follow-up of sexual health.

Indexed as

AndrogenErectile dysfunctionHypogonadismLymphomaSexual healthSurvivorTestosteroneTestosterone deficiency

Identifiers

PMID38961916
PMCPMC11219276

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.