Evidence map›Paper›PMID 38961847›Full record

ArticleAmerican journal of physiology. Renal physiology2024

Deletion of KS-WNK1 promotes NCC activation by increasing WNK1/4 abundance.

Mohammed Z Ferdaus, Andrew S Terker, Rainelli B Koumangoye, Lama Al-Qusairi, Paul A Welling, Eric Delpire

Abstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. The Story of Aldosterone Escape.Journal of the American Society of Nephrology : JASN · 2026
    Review
  3. Article
  4. Article
  5. The evolving concepts of KS-WNK1 effect on NCC activity.American journal of physiology. Renal physiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohammed Z FerdausDepartment of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States.ORCID 0000-0002-4860-5506
Andrew S TerkerDivision of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States.ORCID 0000-0003-1498-9043
Rainelli B KoumangoyeDepartment of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States.ORCID 0000-0002-5963-8987
Lama Al-QusairiDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0002-2956-2811
Paul A WellingDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0002-0719-8705
Eric DelpireDepartment of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States.ORCID 0000-0002-3702-1599

Funding

WNK-SPAK signaling in the Distal NephronR01DK093501 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire, Paul A Welling · 2012 to 2026
$12.1M
Molecular of ROMK Channel FunctionR01DK054231 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI Paul A Welling · 1998 to 2026
$7.7M
OXGR1 in Renal Intercalated Cells, Salt Transport and Diuretic EfficacyR01DK110375 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire, SUSAN MARIE WALL · 2017 to 2026
$6.7M
Polarized Trafficking of K+ Channels in the KidneyR01DK063049 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI WELLING, PAUL A · 2003 to 2016
$4.7M
Innovative therapeutic approaches to treat chronic kidney diseaseDP5OD033412 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI TERKER, ANDREW S. · 2022 to 2025
$2.2M
Fondation Leducq (Leducq Foundation) 17CVD05HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK093501NIDDK NIH HHS R01 DK054231NIDDK NIH HHS R01 DK063049NIDDK NIH HHS R01 DK093501NIDDK NIH HHS R01 DK110375NIH HHS DP5 OD033412
6 · The paper itself

Abstract

Dietary potassium deficiency causes stimulation of sodium reabsorption leading to an increased risk in blood pressure elevation. The distal convoluted tubule (DCT) is the main rheostat linking plasma K

Indexed as

Kidney Tubules, DistalProtein Serine-Threonine KinasesSolute Carrier Family 12, Member 3WNK Lysine-Deficient Protein Kinase 1AnimalsMaleMiceMice, Inbred C57BLMice, KnockoutPhosphorylationPotassiumPotassium, DietaryPotassiumPotassium, DietaryPrkwnk4 protein, mouseProtein Serine-Threonine KinasesSlc12a3 protein, mouseSolute Carrier Family 12, Member 3Wnk1 protein, mouseWNK Lysine-Deficient Protein Kinase 1distal convoluted tubuleKS-WNK1Na-Cl cotransporterpotassium deficiencyWNK kinases

Identifiers

PMID38961847
PMCPMC11460338

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.