Evidence map›Paper›PMID 38961691›Full record

ArticleJournal of veterinary internal medicine

Early progression during or after cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy indicates poor outcome with rescue protocols in dogs with multicentric lymphoma.

Ashley S Parker, Jenna H Burton, Kaitlin M Curran, Amber Wolf-Ringwall, Douglas H Thamm

Abstract read
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In one paragraph

Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ashley S ParkerFlint Animal Cancer Center, Colorado State University, Fort Collins, Colorado, USA.ORCID https://orcid.org/0009-0001-2630-8674
Jenna H BurtonFlint Animal Cancer Center, Colorado State University, Fort Collins, Colorado, USA.ORCID https://orcid.org/0000-0002-1895-8298
Kaitlin M CurranCarlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA.
Amber Wolf-RingwallRed River Animal Emergency Hospital & Referral Center, Fargo, North Dakota, USA.
Douglas H ThammFlint Animal Cancer Center, Colorado State University, Fort Collins, Colorado, USA.ORCID https://orcid.org/0000-0002-8914-7767

Funding

A randomized, blinded, placebo-controlled field study to determine the efficacy and safety of TANOVEA-CA1 (rabacfosadine for injection) in dogs. Protocol Number VC-014.R01FD006323 · FDA · VETDC, INC. · PI DONOGHUE, ANN · 2018 to 2020
$338k
Elanco Animal HealthFDA HHS R01 FD006323U.S. Food and Drug Administration 1R01 FD006323-01VetDC, Inc
6 · The paper itself

Abstract

backgroundDogs with lymphoma that fail cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy (CHOP) before completion of their protocol are commonly thought to have poor long-term outcome, but no previous studies have evaluated the effect of early relapse on progression-free interval (PFI) or overall survival time (OST) for patients undergoing rescue chemotherapy.

objectiveCorrelate rescue treatment outcomes in dogs with multicentric lymphoma with outcomes after 1st-line CHOP chemotherapy.

methodsData were collected from 6 previous retrospective or prospective studies in 187 dogs with multicentric lymphoma that received 1st-line CHOP chemotherapy and then received either lomustine (CCNU), L-asparaginase and prednisone (LAP), or rabacfosadine (RAB, Tanovea), with or without prednisone or L-asparaginase.

resultsThe PFI after initiation of CHOP chemotherapy was significantly associated with response rate postprogression, PFI, and postrescue survival time (ST) for both rescue protocols. Immunophenotype (B- vs T-cell) was not significantly associated with response, PFI or OST for LAP but was significantly associated with response and PFI for RAB.

conclusionDogs that experience short PFI during or after 1st-line CHOP chemotherapy had lower response rates to rescue treatment, with shorter PFI and ST. Immunophenotype did not significantly affect outcome with LAP but was associated with PFI for RAB.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsCyclophosphamideDog DiseasesDoxorubicinLymphomaPrednisoneVincristineAlanineAnimalsAsparaginaseDisease ProgressionDogsFemaleLomustineMaleProspective StudiesAlanineAsparaginaseCyclophosphamideDoxorubicinLomustinePrednisonePurinesrabacfosadineVincristinecaninehematopoieticmulticentricremissionspecies

Identifiers

PMID38961691
PMCPMC11256168

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.