Evidence map›Paper›PMID 38961492›Full record

Trial reportTrials2024

A mixed methods process evaluation: understanding the implementation and delivery of HIV prevention services integrated within sexual reproductive health (SRH) with or without peer support amongst adolescents and young adults in rural KwaZulu-Natal, South Africa.

Thembelihle Zuma, Jacob Busang, Sphesihle Hlongwane, Glory Chidumwa, Dumsani Gumede, Manono Luthuli, Jaco Dreyer, Carina Herbst, Nonhlanhla Okesola, Natsayi Chimbindi and 4 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Preventing HIV in women in Africa.Nature medicine · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Thembelihle ZumaAfrica Health Research Institute, KwaZulu-Natal, South Africa. Thembelihle.zuma@ahri.org.ORCID http://orcid.org/0000-0002-8374-2354
Jacob BusangAfrica Health Research Institute, KwaZulu-Natal, South Africa.
Sphesihle HlongwaneAfrica Health Research Institute, KwaZulu-Natal, South Africa.
Glory ChidumwaWits RHI, University of the Witwatersrand, Johannesburg, South Africa.
Dumsani GumedeAfrica Health Research Institute, KwaZulu-Natal, South Africa.
Manono LuthuliAfrica Health Research Institute, KwaZulu-Natal, South Africa.
Jaco DreyerAfrica Health Research Institute, KwaZulu-Natal, South Africa.
Carina HerbstAfrica Health Research Institute, KwaZulu-Natal, South Africa.
Nonhlanhla OkesolaAfrica Health Research Institute, KwaZulu-Natal, South Africa.
Natsayi ChimbindiAfrica Health Research Institute, KwaZulu-Natal, South Africa.
Nuala McGrathAfrica Health Research Institute, KwaZulu-Natal, South Africa.
Lorraine SherrUniversity College London, London, UK.
Janet SeeleyAfrica Health Research Institute, KwaZulu-Natal, South Africa.
Maryam ShahmaneshAfrica Health Research Institute, KwaZulu-Natal, South Africa.

Funding

Maximizing combination HIV prevention, uptake and retention by adolescent girls and young womenR01MH114560 · NIMH · KWAZULU-NATAL RESEARCH INSTITUTE TB-HIV · PI SHAHMANESH, MARYAM · 2017 to 2023
$2.0M
NIH HHS 5R01MH114560-03NIH HHS NIHR 301634NIH HHS RP-2017-08-ST2-008NIMH NIH HHS R01 MH114560Wellcome TrustWellcome Trust 082384/Z/07/ZWellcome Trust 224309/Z/21/Z
6 · The paper itself

Abstract

backgroundCombination prevention interventions, when integrated with community-based support, have been shown to be particularly beneficial to adolescent and young peoples' sexual and reproductive health. Between 2020 and 2022, the Africa Health Research Institute in rural South Africa conducted a 2 × 2 randomised factorial trial among young people aged 16-29 years old (Isisekelo Sempilo) to evaluate whether integrated HIV and sexual and reproductive health (HIV/SRH) with or without peer support will optimise delivery of HIV prevention and care. Using mixed methods, we conducted a process evaluation to provide insights to and describe the implementation of a community-based peer-led HIV care and prevention intervention targeting adolescents and young people.

methodsThe process evaluation was conducted in accordance with the Medical Research Council guidelines using quantitative and qualitative approaches. Self-completed surveys and clinic and programmatic data were used to quantify the uptake of each component of the intervention and to understand intervention fidelity and reach. In-depth individual interviews were used to understand intervention experiences. Baseline sociodemographic factors were summarised for each trial arm, and proportions of participants who accepted and actively engaged in various components of the intervention as well as those who successfully linked to care were calculated. Qualitative data were thematically analysed.

resultsThe intervention was feasible and acceptable to young people and intervention implementing teams. In particular, the STI testing and SRH components of the intervention were popular. The main challenges with the peer support implementation were due to fidelity, mainly because of the COVID-19 pandemic. The study found that it was important to incorporate familial support into interventions for young people's sexual health. Moreover, it was found that psychological and social support was an essential component to combination HIV prevention packages for young people.

conclusionThe results demonstrated that peer-led community-based care that integrates SRH services with HIV is a versatile model to decentralise health and social care. The family could be a platform to target restrictive gender and sexual norms, by challenging not only attitudes and behaviours related to gender among young people but also the gendered structures that surround them.

Indexed as

HIV InfectionsPeer GroupSexual HealthAdolescentAdultDelivery of Health Care, IntegratedFemaleHumansMaleProcess Assessment, Health CareReproductive HealthReproductive Health ServicesRural PopulationSocial SupportSouth AfricaYoung Adult

Identifiers

PMID38961492
PMCPMC11223316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.