Evidence map›Paper›PMID 38961452›Full record

ArticleThe international journal of behavioral nutrition and physical activity2024

Device-measured sedentary time and intensity-specific physical activity in relation to all-cause and cardiovascular disease mortality: the UK Biobank cohort study.

Leandro F M Rezende, Matthew Ahmadi, Gerson Ferrari, Borja Del Pozo Cruz, I-Min Lee, Ulf Ekelund, Emmanuel Stamatakis

Abstract read
In one paragraph

Article in The international journal of behavioral nutrition and physical activity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
  4. Intensity-specific physical activity and mortality in 147,414 adults: a pooled accelerometer analysis.The international journal of behavioral nutrition and physical activity · 2026
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  16. Joint exposure to PMFrontiers in public health · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Leandro F M RezendeDepartment of Preventive Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Matthew AhmadiMackenzie Wearables Research Hub, Charles Perkins Centre, The University of Sydney, Sydney, Australia.
Gerson FerrariEscuela de Ciencias de la Actividad Física, el Deporte y la Salud, Universidad de Santiago de Chile (USACH), Santiago, Chile.
Borja Del Pozo CruzDepartment of Sport Sciences and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, Odense, 5230, Denmark.
I-Min LeeDivision of Preventive Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, USA.
Ulf EkelundDepartment of Sport Medicine, Norwegian School of Sports Sciences, Oslo, Norway.
Emmanuel StamatakisMackenzie Wearables Research Hub, Charles Perkins Centre, The University of Sydney, Sydney, Australia. emmanuel.stamatakis@sydney.edu.au.ORCID http://orcid.org/0000-0001-7323-3225

Funding

Australian Primary Health Care Research Institute, Australian National University APP1194510
6 · The paper itself

Abstract

BACKGROUND AND

aimsUnderstanding the amounts of intensity-specific movement needed to attenuate the association between sedentary time and mortality may help to inform personalized prescription and behavioral counselling. Herein, we examined the joint associations of sedentary time and intensity-specific physical activity with all-cause and cardiovascular disease (CVD) mortality.

methodsProspective cohort study including 73,729 adults from the UK Biobank who wore an Axivity AX3 accelerometer on their dominant wrist for at least 3 days, being one a weekend day, between June 2013 and December 2015. We considered the median tertile values of sedentary time and physical activity in each intensity band to determine the amount of physical activity needed to attenuate the association between sedentary time and mortality.

resultsDuring a median of 6.9 years of follow-up (628,807 person-years), we documented 1521 deaths, including 388 from CVD. Physical activity of any intensity attenuated the detrimental association of sedentary time with mortality. Overall, at least a median of 6 min/day of vigorous physical activity, 30 min/day of MVPA, 64 min/day of moderate physical activity, or 163 min/day of light physical activity (mutually-adjusted for other intensities) attenuated the association between sedentary time and mortality. High sedentary time was associated with higher risk of CVD mortality only among participants with low MVPA (HR 1.96; 95% CI 1.23 to 3.14).

conclusionsDifferent amounts of each physical activity intensity may attenuate the association between high sedentary time and mortality.

Indexed as

AccelerometryCardiovascular DiseasesExerciseSedentary BehaviorAdultAgedCohort StudiesFemaleHumansMaleMiddle AgedProspective StudiesRisk FactorsUK BiobankUnited KingdomAccelerometerAll-cause mortalityCardiovascular disease mortalityPhysical activitySedentary behaviour

Identifiers

PMID38961452
PMCPMC11223286

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.