Trial reportAlzheimer's research & therapy2024
Nutrition guidance within a multimodal intervention improves diet quality in prodromal Alzheimer's disease: Multimodal Preventive Trial for Alzheimer's Disease (MIND-AD
Trial report in Alzheimer's research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03249688 (Multimodal Preventive Trial for Alzheimer's Disease), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multimodal Preventive Trial for Alzheimer's Disease (MIND-ADmini Pilot Trial)
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk reduction and precision prevention across the Alzheimer's disease continuum: a systematic review of clinical trials combining multidomain lifestyle interventions and pharmacological or nutraceutical approaches.The journal of prevention of Alzheimer's disease · 2025Pooled it
- Alzheimer's disease: from molecular pathways to therapies.Molecular biomedicine · 2026Review
- Dietary intervention among young cancer survivors within the CARE for CAYA program.Journal of cancer survivorship : research and practice · 2026Article
- Sex differences in association of cMIND diet with all-cause mortality in Chinese older adults: a 10-year national cohort study.BMC public health · 2026Observational
- From plate to brain: role of mediators and moderators on the impact of diet on Alzheimer's disease.Frontiers in nutrition · 2026Review
- Non-pharmacological strategies for the management of Alzheimer's disease.Dementia & neuropsychologia · 2026Review
- Association between low magnesium status and new-onset dementia in the general population: a propensity score-matched cohort study.Frontiers in nutrition · 2026Article
- Nutrition, functional status, polypharmacy, and digestive disturbances in institutionalized patients with dementia: insights from comprehensive screening at admission.Frontiers in nutrition · 2026Article
- Advancements in non-pharmaceutical interventions for Alzheimer's disease management: an update review.Frontiers in aging neuroscience · 2026Review
- The role of nutrition and multimodal lifestyle interventions in Alzheimer's prevention and management: a mini-review.Frontiers in nutrition · 2026Review
- Environmental Stressors and Neuroinflammation: Linking Climate Change to Alzheimer's Disease.Current issues in molecular biology · 2025Review
- The long-term neuroprotective effect of MIND and Mediterranean diet on patients with Alzheimer's disease.Scientific reports · 2025Article
- BRAIN-Diabetes: a randomised trial to test the feasibility of an adapted FINGER multidomain intervention in adults with type 2 diabetes living in rural border regions of Ireland.European journal of ageing · 2025Article
- Unveiling the therapeutic potential of natural products in Alzheimer's disease: insights fromFrontiers in pharmacology · 2025Review
- Mediterranean Diet and Lifestyle in Persons with Mild to Moderate Alzheimer's Disease.Nutrients · 2024Article
- Therapeutic advances in Alzheimer's disease: Current strategies and future possibilities.Tzu chi medical journalReview
- Diagnostic and inclusion criteria in Alzheimer's disease clinical trials: A systematic review of the past decade.Journal of Alzheimer's disease reportsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
backgroundMultimodal lifestyle interventions can benefit overall health, including cognition, in populations at-risk for dementia. However, little is known about the effect of lifestyle interventions in patients with prodromal Alzheimer's disease (AD). Even less is known about dietary intake and adherence to dietary recommendations within this population making it difficult to design tailored interventions for them.
methodA 6-month MIND-AD
resultsThe dietary quality in the intervention groups, pooled together, improved compared to that of the control group at the end of the study, as measured with by HDI (p = 0.026) and MEDAS (p = 0.008). The lifestyle-only group improved significantly more in MEDAS (p = 0.046) and almost significantly in HDI (p = 0.052) compared to the control group, while the lifestyle + medical food group improved in both HDI (p = 0.042) and MEDAS (p = 0.007) during the study. There were no changes in macro- or micronutrient intake for the intervention groups at follow-up; however, the intakes in the control group declined in several vitamins and minerals when adjusted for energy intake.
conclusionThese results suggest that dietary intervention as part of multimodal lifestyle interventions is feasible and results in improved dietary quality in a population with prodromal AD. Nutrient intakes remained unchanged in the intervention groups while the control group showed a decreasing nutrient density.
trial registrationClinicalTrials.gov NCT03249688, 2017-07-08.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.