Evidence map›Paper›PMID 38961351›Full record

ArticleBMC pediatrics2024

Association of selected adipokines with vitamin D deficiency in children with inflammatory bowel disease.

Milos Geryk, Veronika Kucerova, Maria Velganova-Veghova, Hana Foltenova, Katerina Bouchalova, David Karasek, Martin Radvansky, Eva Karaskova

Abstract read
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In one paragraph

Article in BMC pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Milos GerykDepartment of Pediatrics, University Hospital Olomouc, Faculty of Medicine and Dentistry Palacky University Olomouc, Olomouc, Czech Republic.
Veronika KucerovaDepartment of Clinical Biochemistry, University Hospital Olomouc, Olomouc, Czech Republic.
Maria Velganova-VeghovaDepartment of Pediatrics, University Hospital Olomouc, Faculty of Medicine and Dentistry Palacky University Olomouc, Olomouc, Czech Republic.
Hana FoltenovaDepartment of Pediatrics, University Hospital Olomouc, Faculty of Medicine and Dentistry Palacky University Olomouc, Olomouc, Czech Republic.
Katerina BouchalovaDepartment of Pediatrics, University Hospital Olomouc, Faculty of Medicine and Dentistry Palacky University Olomouc, Olomouc, Czech Republic.
David Karasek3rd Department of Internal Medicine - Nephrology, Rheumatology and Endocrinology, University Hospital Olomouc, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic.
Martin RadvanskyDepartment of Computer Science, Faculty of Electrical Engineering and Computer Science, VSB-Technical University of Ostrava, Ostrava - Poruba, Czech Republic.
Eva KaraskovaDepartment of Pediatrics, University Hospital Olomouc, Faculty of Medicine and Dentistry Palacky University Olomouc, Olomouc, Czech Republic. eva.karaskova@fnol.cz.

Funding

Ministerstvo Zdravotnictví Ceské Republiky MH CZ DRO (FNOl, 00098892)Palacky University Olomouc IGA LF 2023_037Palacky University Olomouc IGA LF 2024_040
6 · The paper itself

Abstract

backgroundAdipose tissue is significantly involved in inflammatory bowel disease (IBD). Vitamin D can affect both adipogenesis and inflammation. The aim of this study was to compare the production of selected adipokines, potentially involved in the pathogenesis of IBD - adiponectin, resistin, retinol binding protein 4 (RBP-4), adipocyte fatty acid binding protein and nesfatin-1 in children with IBD according to the presence of 25-hydroxyvitamin D (25(OH)D) deficiency.

methodsThe study was conducted as a case-control study in pediatric patients with IBD and healthy children of the same sex and age. In addition to adipokines and 25(OH)D, anthropometric parameters, markers of inflammation and disease activity were assessed in all participants.

resultsChildren with IBD had significantly higher resistin levels regardless of 25(OH)D levels. IBD patients with 25(OH)D deficiency only had significantly lower RBP-4 compared to healthy controls and also compared to IBD patients without 25(OH)D deficiency. No other significant differences in adipokines were found in children with IBD with or without 25(OH)D deficiency. 25(OH)D levels in IBD patients corelated with RBP-4 only, and did not correlate with other adipokines.

conclusionsWhether the lower RBP-4 levels in the 25(OH)D-deficient group of IBD patients directly reflect vitamin D deficiency remains uncertain. The production of other adipokines does not appear to be directly related to vitamin D deficiency.

Indexed as

AdipokinesVitamin DVitamin D DeficiencyAdiponectinAdolescentBiomarkersCalcium-Binding ProteinsCase-Control StudiesChildDNA-Binding ProteinsFatty Acid-Binding ProteinsFemaleHumansInflammatory Bowel DiseasesMaleNucleobindins25-hydroxyvitamin DAdipokinesAdiponectinBiomarkersCalcium-Binding ProteinsDNA-Binding ProteinsFABP4 protein, humanFatty Acid-Binding ProteinsNUCB2 protein, humanNucleobindinsRBP4 protein, humanResistinRetinol-Binding Proteins, PlasmaVitamin D25-hydroxyvitamin DAdipocyte fatty acid binding proteinAdiponectinInflammatory bowel diseaseNesfatin-1ResistinRetinol-binding protein 4

Identifiers

PMID38961351
PMCPMC11223338

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.