Evidence map›Paper›PMID 38961335›Full record

ArticleJournal of neurodevelopmental disorders2024

Developmental change of brain volume in Rett syndrome in Taiwan.

Tz-Yun Jan, Lee-Chin Wong, Chia-Jui Hsu, Chien-Feng Judith Huang, Steven Shinn-Forng Peng, Wen-Yih Isaac Tseng, Wang-Tso Lee

Abstract read
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In one paragraph

Article in Journal of neurodevelopmental disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tz-Yun JanGraduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan.
Lee-Chin WongDepartment of Pediatrics, Cathay General Hospital, Taipei, Taiwan.
Chia-Jui HsuDepartment of Pediatrics, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan.
Chien-Feng Judith HuangInstitute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan.
Steven Shinn-Forng PengDepartment of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Wen-Yih Isaac TsengInstitute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan.
Wang-Tso LeeGraduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan. wangtsolee@ntu.edu.tw.ORCID 0000-0003-3231-9764

Funding

National Taiwan University Hospital Joint Research Program 105-FTN27National Taiwan University Hospital Joint Research Program 106-FTN24National Taiwan University Hospital Joint Research Program 107- FTN22
6 · The paper itself

Abstract

objectiveRett syndrome (RTT) is characterized by neurological regression. This pioneering study investigated the effect of age on brain volume reduction by analyzing magnetic resonance imaging findings in participants with RTT, ranging from toddlers to adults.

methodsFunctional evaluation and neuroimaging were performed. All scans were acquired using a Siemens Tim Trio 3 T scanner with a 32-channel head coil.

resultsThe total intracranial volume and cerebral white matter volume significantly increased with age in the control group compared with that in the RTT group (p < 0.05). Cortical gray matter volume reduction in the RTT group continued to increase in bilateral parietal lobes and left occipital lobes (p < 0.05). The differences in cortical gray matter volume between typically developing brain and RTT-affected brain may tend to continuously increase until adulthood in both temporal lobes although not significant after correction for multiple comparison.

conclusionsA significant reduction in brain volume was observed in the RTT group. Cortical gray matter volume in the RTT group continued to reduce in bilateral parietal lobes and left occipital lobes. These results provide a baseline for future studies on the effect of RTT treatment and related neuroscience research.

Indexed as

BrainMagnetic Resonance ImagingRett SyndromeAdolescentAdultChildChild, PreschoolFemaleGray MatterHumansMaleOrgan SizeTaiwanWhite MatterYoung AdultBrain volumeDevelopmental trajectoriesGray matter volumeMagnetic resonance imageRett syndromeTotal intracranial volume

Identifiers

PMID38961335
PMCPMC11223417

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.