ArticleBMC cardiovascular disorders2024
The association between systemic inflammation markers and paroxysmal atrial fibrillation.
Article in BMC cardiovascular disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Preprocedural systemic immune-inflammation index predicts atrial fibrillation recurrence after catheter ablation: A systematic review and meta-analysis.Biomolecules & biomedicine · 2026Pooled it
- Inflammation and day-to-day occurrence of atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Trial
- Review
- The Relationship Between the Systemic Immune Inflammatory Index and Atrial Fibrillation in Heart Failure with Preserved Ejection Fraction.The Eurasian journal of medicine · 2026Article
- The Relationship Between Atrial Fibrillation and the Systemic Immune Inflammation Index in Well-Controlled Hypertensive Patients with Newly Developed Atrial Fibrillation.Journal of clinical medicine · 2026Article
- Admission systemic immune-inflammatory index predicts long-term mortality in patients with acute ischemic stroke: a retrospective analysis of the MIMIC-III database.Intensive care medicine experimental · 2026Article
- Joint association of estimated glucose disposal rate and aggregate index of systemic inflammation with mortality in general population: a nationwide prospective cohort study.Cardiovascular diabetology · 2026Article
- Development and validation of a risk nomogram for predicting recurrence in patients with non-valvular atrial fibrillation after radiofrequency catheter ablation.BMC medical informatics and decision making · 2026Article
- Association between complete blood cell count-derived inflammatory indices and left atrial thrombus in patients with nonvalvular atrial fibrillation: a cross-sectional study.Frontiers in medicine · 2026Article
- A Review on the Role of Oral Bacteria in Stroke.International journal of molecular sciences · 2025Review
- The aggregate index of systemic inflammation (AISI) and the risk of all-cause, cardiovascular, and cardio-cerebrovascular mortality in congestive heart failure patients: results from NHANES 1999-2018.Scientific reports · 2025Article
- Machine Learning-Based Immuno-Inflammatory Index Integrating Clinical Characteristics for Predicting Coronary Artery Plaque Rupture.Immunity, inflammation and disease · 2025Article
- Evaluating inflammatory status to predict atrial fibrillation recurrence following ablation: The role of systemic immune-inflammation index.World journal of cardiology · 2025Article
- The association between blood count based inflammatory markers and the risk of atrial fibrillation heart failure and cardiovascular mortality.Scientific reports · 2025Article
- Aggregate index of systemic inflammation as a novel prognostic biomarker in Chinese patients with acute decompensated heart failure: a population-based real-world study.Frontiers in endocrinology · 2025Article
- Association between systemic inflammation response index and atrial fibrillation in chronic obstructive pulmonary disease: a multicenter cross-sectional study.Frontiers in medicine · 2025Article
- The association between the systemic immune-inflammation index and in-hospital mortality among acute ischemic stroke with atrial fibrillation patients undergoing intravenous thrombolysis.Frontiers in cardiovascular medicine · 2025Article
- The Validation of a Nomogram for Predicting Recurrence in Patients with Non-Valvular Atrial Fibrillation Post-Ablation.Clinical interventions in aging · 2025Article
- Association and impact of inflammatory markers and cardiac structure on atrial fibrillation risk: a study integrating NHANES with real-world data.Frontiers in cardiovascular medicine · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundSystemic inflammation markers have recently been identified as being associated with cardiac disorders. However, limited research has been conducted to estimate the pre-diagnostic associations between these markers and paroxysmal atrial fibrillation (PAF). Our aim is to identify potential biomarkers for early detection of PAF.
methods91 participants in the PAF group and 97 participants in the non-PAF group were included in this study. We investigated the correlations between three systemic inflammation markers, namely the systemic immune inflammation index (SII), system inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI), and PAF.
resultsThe proportion of patients with PAF gradually increased with increasing logSII, logSIRI, and logAISI tertiles. Compared to those in the lowest tertiles, the PAF risks in the highest logSII and logSIRI tertiles were 3.2-fold and 2.9-fold, respectively. Conversely, there was no significant correlation observed between logAISI and PAF risk within the highest tertile of logAISI. The restricted cubic splines (RCS) analysis revealed a non-linear relationship between the elevation of systemic inflammation markers and PAF risk. Specifically, the incidence of PAF is respectively increased by 56%, 95%, and 150% for each standard deviation increase in these variables. The ROC curve analysis of logSII, logSIRI and logAISI showed that they had AUC of 0.6, 0.7 and 0.6, respectively. It also demonstrated favorable sensitivity and specificity of these systemic inflammation markers in detecting the presence of PAF.
conclusionsIn conclusion, our study reveals significant positive correlations between SII, SIRI, and AISI with the incidence of PAF.
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