Evidence map›Paper›PMID 38961320›Full record

ArticleBMC neurology2024

Severe CSF immune cell alterations in cryptococcal meningitis gradually resolve during antifungal therapy.

Christine Dambietz, Michael Heming, Tobias J Brix, Andreas Schulte-Mecklenbeck, Phil-Robin Tepasse, Catharina C Gross, Jonel Trebicka, Heinz Wiendl, Gerd Meyer Zu Hörste

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christine DambietzDepartment of Neurology With Institute of Translational Neurology, University Hospital Münster, Albert-Schweitzer-Campus 1, Bldg A1 48149, Münster, Germany.
Michael HemingDepartment of Neurology With Institute of Translational Neurology, University Hospital Münster, Albert-Schweitzer-Campus 1, Bldg A1 48149, Münster, Germany.
Tobias J BrixInstitute of Medical Informatics, University of Münster, Münster, Germany.
Andreas Schulte-MecklenbeckDepartment of Neurology With Institute of Translational Neurology, University Hospital Münster, Albert-Schweitzer-Campus 1, Bldg A1 48149, Münster, Germany.
Phil-Robin TepasseDepartment of Gastroenterology, Hepatology, Endocrinology and Infectiology, University Hospital Münster, Münster, Germany.
Catharina C GrossDepartment of Neurology With Institute of Translational Neurology, University Hospital Münster, Albert-Schweitzer-Campus 1, Bldg A1 48149, Münster, Germany.
Jonel TrebickaDepartment of Gastroenterology, Hepatology, Endocrinology and Infectiology, University Hospital Münster, Münster, Germany.
Heinz WiendlDepartment of Neurology With Institute of Translational Neurology, University Hospital Münster, Albert-Schweitzer-Campus 1, Bldg A1 48149, Münster, Germany.
Gerd Meyer Zu HörsteDepartment of Neurology With Institute of Translational Neurology, University Hospital Münster, Albert-Schweitzer-Campus 1, Bldg A1 48149, Münster, Germany. gerd.meyerzuhoerste@ukmuenster.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cryptococcal meningitis (CM) is a severe fungal disease in immunocompromised patients affecting the central nervous system (CNS). Host response and immunological alterations in the cerebrospinal fluid (CSF) after invasion of Cryptococcus neoformans to the central nervous system have been investigated before but rigorous and comprehensive studies examining cellular changes in the CSF of patients with cryptococccal meningitis are still rare. We retrospectively collected CSF analysis and flow cytometry data of CSF and blood in patients with CM (n = 7) and compared them to HIV positive patients without meningitis (n = 13) and HIV negative healthy controls (n = 7). Within the group of patients with CM we compared those with HIV infection (n = 3) or other immunocompromised conditions (n = 4). Flow cytometry analysis revealed an elevation of natural killer cells and natural killer T cells in the CSF and blood of HIV negative patients with CM, pointing to innate immune activation in early stages after fungal invasion. HIV positive patients with CM exhibited stronger blood-CSF-barrier disruption. Follow-up CSF analysis over up to 150 days showed heterogeneous cellular courses in CM patients with slow normalization of CSF after induction of antifungal therapy.

Indexed as

Antifungal AgentsMeningitis, CryptococcalAdultAgedFemaleFlow CytometryHIV InfectionsHumansKiller Cells, NaturalMaleMiddle AgedRetrospective StudiesAntifungal AgentsAntifungal therapyCryptococcus neoformansFlow cytometryFungal meningitisHIVIntrathecal immunity

Identifiers

PMID38961320
PMCPMC11221170

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.