ArticleNature2024
Adenosine signalling to astrocytes coordinates brain metabolism and function.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Photobiomodulation and sleep quality: systematic review and meta-analysis.Lasers in medical science · 2026Pooled it
- The safety and efficacy of gamma frequency auditory and visual stimulation in the treatment of alzheimer's disease: a systematic review and meta-analysis.Translational psychiatry · 2025Pooled it
- Adenosine receptor signaling in vascular diseases: from molecular mechanisms to targeted therapeutics.Acta pharmacologica Sinica · 2026Review
- Clemastine alleviates cognitive dysfunction after SAH by targeting neuronal CNTN1 to regulate the ADA-adenosine pathway.Acta pharmacologica Sinica · 2026Article
- Disrupted TFEB/GDNF-cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- From metabolic intermediary to neurotransmitter: purinergic signaling in neurophysiology and vulnerability of brain circuits.Bioscience reports · 2026Review
- Brain mitochondria as key drivers of cognition and behaviour.Nature reviews. Neuroscience · 2026Review
- Mechanism-Driven Nanoformulations for Cognitive Impairment Induced by Intermittent Hypoxia and Periodontitis.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Bridging the gap: neuroinflammation and the dawn of precision medicine in amyotrophic lateral sclerosis.Translational neurodegeneration · 2026Review
- The sleep-wake cycle: molecular mechanisms, disorders, and therapeutic targets in the context of energy metabolism.Signal transduction and targeted therapy · 2026Review
- Activity-dependent protein synthesis in neurons requires microglial-metabolic coupling.Cell metabolism · 2026Article
- Low Dose Ketamine Preconditions Astrocyte Mitochondria to Achieve Antidepressant Efficacy via Adenosine, Humanin, and Melatonin Upregulation and Efflux.Alpha psychiatry · 2026Article
- Crosstalk of noradrenergic CaCell communication and signaling : CCS · 2026Article
- Energy Homeostasis Disruption in Neurological Disorders: Mitochondrial Dysfunction, High-Energy Phosphate Transfer, and Extracellular ATP-Dependent Purinergic Dysregulation.International journal of molecular sciences · 2026Review
- Light Exposure Ameliorates Tau-Induced Deficits via Adenosine Signaling and Mitochondrial Quality Control inBiomedicines · 2026Article
- Role Shift of Glial Cells from Physiology to Pathology in Alzheimer's Disease: The Regulatory Impact of Exercise.Neuroscience bulletin · 2026Review
- Astrocyte activation in the ventrolateral medulla modulates breathing and arousal states.Nature communications · 2026Article
- ALS-FTD-linked CCNFJournal of neuroinflammation · 2026Article
- Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury.CNS neuroscience & therapeutics · 2026Review
- Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Shefeeq M TheparambilCentre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK. s.theparambil@ucl.ac.uk.ORCID 0000-0001-5751-8829
Olga KopachInstitute of Neurology, University College London, London, UK.ORCID 0000-0002-3921-3674
Alice BragaCentre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK.
Shereen NizariCentre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK.
Patrick S HosfordCentre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK.
Virag Sagi-KissSection of Bioanalytical Chemistry, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Anna HadjihambiThe Roger Williams Institute of Hepatology, Foundation for Liver Research & Faculty of Life Sciences and Medicine, King's College London, London, UK.
Christos KonstantinouThe Roger Williams Institute of Hepatology, Foundation for Liver Research & Faculty of Life Sciences and Medicine, King's College London, London, UK.
Noemi EsterasInstitute of Neurology, University College London, London, UK.
Ana Gutierrez Del ArroyoTranslational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK.ORCID 0000-0003-1240-4654
Gareth L AcklandTranslational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK.
Anja G TeschemacherPhysiology, Pharmacology, and Neuroscience, University of Bristol, Bristol, UK.
Nicholas DaleSchool of Life Sciences, University of Warwick, Coventry, UK.ORCID 0000-0003-2196-2949
Tobias EckleDepartment of Anesthesiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Petros AndrikopoulosSection of Biomolecular Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0002-1555-3498
Dmitri A RusakovInstitute of Neurology, University College London, London, UK.ORCID 0000-0001-9539-9947
Sergey KasparovPhysiology, Pharmacology, and Neuroscience, University of Bristol, Bristol, UK.ORCID 0000-0002-1824-1764
Alexander V GourineCentre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK. a.gourine@ucl.ac.uk.ORCID 0000-0003-3068-491X
Funding
Intense Light Therapy for Perioperative Cardio-ProtectionR01HL122472 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI DE LA GARZA ECKLE, TOBIAS · 2015 to 2019
$1.9MPeriod in Cardio ProtectionK08HL102267 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI DE LA GARZA ECKLE, TOBIAS · 2010 to 2014
$658kTargeting the endothelial clock to treat perioperative myocardial ischemiaR56HL156955 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI DE LA GARZA ECKLE, TOBIAS · 2022 to 2022
$383kEuropean Research Council 323113Medical Research Council MR/Y010051/1NHLBI NIH HHS K08 HL102267NHLBI NIH HHS R01 HL122472NHLBI NIH HHS R56 HL156955Wellcome Trust 223131
Abstract
Brain computation performed by billions of nerve cells relies on a sufficient and uninterrupted nutrient and oxygen supply
Indexed as
AdenosineAstrocytesBrainEnergy MetabolismNeuronsSignal TransductionAnimalsCyclic AMPCyclic AMP-Dependent Protein KinasesFemaleGlucoseHippocampusLactic AcidMaleMiceMice, Inbred C57BLAdenosineCyclic AMPCyclic AMP-Dependent Protein KinasesGlucoseLactic AcidReceptor, Adenosine A2B
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.