ArticleNature2024
Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Recent advances in antituberculosis drugs and therapeutics: from mechanistic breakthroughs to clinical translation.Molecular biomedicine · 2026Review
- Targeting Latent Tuberculosis Using Hypoxia-Activated Prodrugs of Bedaquiline Analogues.ACS medicinal chemistry letters · 2026Article
- Article
- A planar dimer of bovine ATP synthase.Cell death and differentiation · 2026Article
- Decoding the Hot-Mitochondrion Paradox.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Cu-Catalyzed dynamic kinetic asymmetric allylation enabled enantioselective assembly of sterically congested triaryl tertiary alcohols.Nature communications · 2026Article
- Bedaquiline inhibits the ATP synthase leak channel and prevents glutamate-induced neuronal death.Biophysical reports · 2026Article
- Minimal Computational Framework for Systematic Identification of Antimicrobial Targets.bioRxiv : the preprint server for biology · 2026Article
- Bedaquiline inhibits the ATP synthase leak channel and prevents glutamate-induced neuronal death.bioRxiv : the preprint server for biology · 2026Article
- Drug Exposure Dictates Evolutionary Dynamics of Drug-Resistant Tuberculosis: A Longitudinal Cohort Study in Beijing, China.Infection and drug resistance · 2026Article
- Combating Drug Resistance inBioinformatics and biology insights · 2026Article
- Article
- Investigation of mitochondrial inner membrane ion conductance by planar lipid bilayer electrophysiology.Frontiers in physiology · 2026Article
- Design, Synthesis, and Biological Evaluation of Mono- and Diamino-Substituted Squaramide Derivatives as Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthase.Journal of medicinal chemistry · 2025Article
- Remission spectroscopy resolves the mechanism of action of bedaquiline within living mycobacteria.Nature communications · 2025Article
- Verapamil Suppresses the Development of Resistance Against Anti-Tuberculosis Drugs in Mycobacteria.International journal of molecular sciences · 2025Article
- Scaffold Hopping in Tuberculosis Drug Discovery: Principles, Applications, and Case Studies.Journal of medicinal chemistry · 2025Review
- The N-Terminal Extension of theAntibiotics (Basel, Switzerland) · 2025Article
- Real-world effectiveness and safety of prolonged bedaquiline course in the treatment of drug-resistant tuberculosis-a multi-center retrospective cohort study in a country with a high burden of drug-resistant tuberculosis.Microbiology spectrum · 2025Article
- Identification ofMicrobiology spectrum · 2025Article
Corrections and comments
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Authors and funding
19 authors.
Yuying Zhang *State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China.
Yuezheng Lai *State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China.
Shan ZhouState Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China.
Ting RanInnovative Center for Pathogen Research, Guangzhou National Laboratory, Guangzhou, China.ORCID 0000-0002-1387-4634
Yue ZhangState Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China.
Ziqing ZhaoState Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China.
Ziyan FengState Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China.
Long YuState Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China.
Jinxu XuState Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China.
Kun ShiState Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China.
Jianyun WangState Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China.
Yu PangBeijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Research Institute, Capital Medical University, Beijing, China.
Liang LiBeijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Research Institute, Capital Medical University, Beijing, China.
Hongming ChenInnovative Center for Pathogen Research, Guangzhou National Laboratory, Guangzhou, China.
Luke W GuddatSchool of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia.ORCID 0000-0002-8204-8408
Yan GaoShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China. gaoyan@shanghaitech.edu.cn.ORCID 0000-0002-0364-6427
Fengjiang LiuInnovative Center for Pathogen Research, Guangzhou National Laboratory, Guangzhou, China. liu_fengjiang@gzlab.ac.cn.ORCID 0000-0002-9400-308X
Zihe RaoState Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China. raozh@tsinghua.edu.cn.
Hongri GongState Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China. gonghr@nankai.edu.cn.ORCID 0000-0002-2596-7635
Funding
National Key R&D Program of ChinaNational Natural Science Foundation of ChinaShanghai Rising-Star Program
Abstract
Bedaquiline (BDQ), a first-in-class diarylquinoline anti-tuberculosis drug, and its analogue, TBAJ-587, prevent the growth and proliferation of Mycobacterium tuberculosis by inhibiting ATP synthase
Indexed as
Antitubercular AgentsDiarylquinolinesImidazolesMitochondrial Proton-Translocating ATPasesMycobacterium tuberculosisPiperidinesPyridinesBinding SitesCryoelectron MicroscopyHumansModels, MolecularProtein SubunitsAntitubercular AgentsbedaquilineDiarylquinolinesImidazolesMitochondrial Proton-Translocating ATPasesPiperidinesProtein SubunitsPyridinestelacebec
Identifiers
PMID
38961288What OpenQuestion holds
Textmetadata
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.