ArticleCommunications biology2024
AANAT1 regulates insect midgut detoxification through the ROS/CncC pathway.
Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Insecticide Resistance Dynamics and Gene Screening inInsects · 2026Article
- Understanding the Chemosensory and Detoxification Mechanisms in the Oriental Fruit Fly,Insects · 2026Article
- Metagenomic analysis of gut bacteria in different developmental instars ofMicrobiology spectrum · 2026Article
- Susceptibility to the Neonicotinoid Pesticide Imidacloprid Is Linked to Life History Regulation in Honey Bees (Apis mellifera L.).Molecular ecology · 2026Article
- Virus-mediated changes in insect vector tolerance to a neonicotinoid insecticide.Scientific reports · 2026Article
- Toxicodynamic Assessment of Aqueous Neem (Toxins · 2025Article
- Knockdown ofFrontiers in physiology · 2024Article
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Authors and funding
6 authors.
Funding
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Abstract
Insecticide resistance has been a problem in both the agricultural pests and vectors. Revealing the detoxification mechanisms may help to better manage insect pests. Here, we showed that arylalkylamine N-acetyltransferase 1 (AANAT1) regulates intestinal detoxification process through modulation of reactive oxygen species (ROS)-activated transcription factors cap"n"collar isoform-C (CncC): muscle aponeurosis fibromatosis (Maf) pathway in both the oriental fruit fly, Bactrocera dorsalis, and the arbovirus vector, Aedes aegypti. Knockout/knockdown of AANAT1 led to accumulation of biogenic amines, which induced a decreased in the gut ROS level. The reduced midgut ROS levels resulted in decreased expression of CncC and Maf, leading to lower expression level of detoxification genes. AANAT1 knockout/knockdown insects were more susceptible to insecticide treatments. Our study reveals that normal functionality of AANAT1 is important for the regulation of gut detoxification pathways, providing insights into the mechanism underlying the gut defense against xenobiotics in metazoans.
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