Evidence map›Paper›PMID 38961155›Full record

ReviewNature2024

Expanding chemistry through in vitro and in vivo biocatalysis.

Elijah N Kissman, Max B Sosa, Douglas C Millar, Edward J Koleski, Kershanthen Thevasundaram, Michelle C Y Chang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Reprogramming NAD(P)Angewandte Chemie (International ed. in English) · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Biocatalytic Regioselective C-Formylation of Resorcinol Derivatives.Angewandte Chemie (International ed. in English) · 2026
    Article
  13. Nanozymes for Energy and Environmental Sustainability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Harnessing Photoenzymatic Systems for Intermolecular C-H Fluorination.Angewandte Chemie (International ed. in English) · 2026
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elijah N Kissman *Department of Chemistry, University of California Berkeley, Berkeley, CA, USA.ORCID 0000-0002-3278-8010
Max B Sosa *Department of Chemistry, University of California Berkeley, Berkeley, CA, USA.ORCID 0009-0008-8230-6535
Douglas C Millar *Department of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, CA, USA.
Edward J KoleskiDepartment of Chemistry, University of California Berkeley, Berkeley, CA, USA.
Kershanthen ThevasundaramDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.
Michelle C Y ChangDepartment of Chemistry, University of California Berkeley, Berkeley, CA, USA. mcchang@berkeley.edu.ORCID 0000-0003-3747-7630

Funding

Univ of Calif Berkeley Chemistry-Biology Interface ProgramT32GM066698 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, CHRISTOPHER J., FRANCIS, MATTHEW B · 2004 to 2023
$7.5M
Discovery and Application of New HalogenasesR01GM134271 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, MICHELLE C · 2020 to 2023
$1.5M
Synthetic Biology Approaches to New Fluorinated PharmaceuticalsR01GM123181 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, MICHELLE C · 2017 to 2020
$1.3M
NIGMS NIH HHS R01 GM123181NIGMS NIH HHS R01 GM134271NIGMS NIH HHS T32 GM066698
6 · The paper itself

Abstract

Living systems contain a vast network of metabolic reactions, providing a wealth of enzymes and cells as potential biocatalysts for chemical processes. The properties of protein and cell biocatalysts-high selectivity, the ability to control reaction sequence and operation in environmentally benign conditions-offer approaches to produce molecules at high efficiency while lowering the cost and environmental impact of industrial chemistry. Furthermore, biocatalysis offers the opportunity to generate chemical structures and functions that may be inaccessible to chemical synthesis. Here we consider developments in enzymes, biosynthetic pathways and cellular engineering that enable their use in catalysis for new chemistry and beyond.

Indexed as

BiocatalysisBiosynthetic PathwaysCell EngineeringEnzymesChemistry Techniques, SyntheticHumansSubstrate SpecificityEnzymes

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.