Evidence map›Paper›PMID 38961153›Full record

ArticleInternational journal of obesity (2005)2024

The metabolic consequences of 'yo-yo' dieting are markedly influenced by genetic diversity.

Senthil Thillainadesan, Aaron Lambert, Kristen C Cooke, Jacqueline Stöckli, Belinda Yau, Stewart W C Masson, Anna Howell, Meg Potter, Oliver K Fuller, Yi Lin Jiang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of obesity (2005), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Fifteen years of the Diversity Outbred mouse model: a review.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Senthil Thillainadesan *Charles Perkins Centre, University of Sydney, Camperdown, NSW, 2006, Australia.
Aaron Lambert *Charles Perkins Centre, University of Sydney, Camperdown, NSW, 2006, Australia.ORCID 0009-0004-1828-7027
Kristen C CookeCharles Perkins Centre, University of Sydney, Camperdown, NSW, 2006, Australia.
Jacqueline StöckliCharles Perkins Centre, University of Sydney, Camperdown, NSW, 2006, Australia.
Belinda YauCharles Perkins Centre, University of Sydney, Camperdown, NSW, 2006, Australia.
Stewart W C MassonCharles Perkins Centre, University of Sydney, Camperdown, NSW, 2006, Australia.
Anna HowellCharles Perkins Centre, University of Sydney, Camperdown, NSW, 2006, Australia.
Meg PotterCharles Perkins Centre, University of Sydney, Camperdown, NSW, 2006, Australia.
Oliver K FullerCharles Perkins Centre, University of Sydney, Camperdown, NSW, 2006, Australia.ORCID 0000-0003-1914-922X
Yi Lin JiangCharles Perkins Centre, University of Sydney, Camperdown, NSW, 2006, Australia.ORCID 0009-0006-3000-4880
Melkam A KebedeCharles Perkins Centre, University of Sydney, Camperdown, NSW, 2006, Australia.
Grant MorahanAustralian Centre for Advancing Diabetes Innovations, Harry Perkins Institute of Medical Research, Nedlands, WA, Australia.
David E JamesCharles Perkins Centre, University of Sydney, Camperdown, NSW, 2006, Australia. david.james@sydney.edu.au.ORCID 0000-0001-5946-5257
Søren MadsenCharles Perkins Centre, University of Sydney, Camperdown, NSW, 2006, Australia. soren.madsen@sydney.edu.au.ORCID 0000-0002-1585-7862
Samantha L HockingCharles Perkins Centre, University of Sydney, Camperdown, NSW, 2006, Australia. samantha.hocking@sydney.edu.au.ORCID 0000-0002-2514-9392

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWeight loss can improve the metabolic complications of obesity. However, it is unclear whether insulin resistance persists despite weight loss and whether any protective benefits are preserved following weight regain (weight cycling). The impact of genetic background on weight cycling is undocumented. We aimed to investigate the effects of weight loss and weight cycling on metabolic outcomes and sought to clarify the role of genetics in this relationship.

methodBoth C57BL/6 J and genetically heterogeneous Diversity Outbred Australia (DOz) mice were alternately fed high fat Western-style diet (WD) and a chow diet at 8-week intervals. Metabolic measures including body composition, glucose tolerance, pancreatic beta cell activity, liver lipid levels and adipose tissue insulin sensitivity were determined.

resultsAfter diet switch from WD (8-week) to chow (8-week), C57BL/6 J mice displayed a rapid normalisation of body weight, adiposity, hyperinsulinemia, liver lipid levels and glucose uptake into adipose tissue comparable to chow-fed controls. In response to the same dietary intervention, genetically diverse DOz mice conversely maintained significantly higher fat mass and insulin levels compared to chow-fed controls and exhibited much more profound interindividual variability than C57BL/6 J mice. Weight cycled (WC) animals were re-exposed to WD (8-week) and compared to age-matched controls fed 8-week WD for the first time (LOb). In C57BL/6 J but not DOz mice, WC animals had significantly higher blood insulin levels than LOb controls. All WC animals exhibited significantly greater beta cell activity than LOb controls despite similar fat mass, glucose tolerance, liver lipid levels and insulin-stimulated glucose uptake in adipose tissue.

conclusionFollowing weight loss, metabolic outcomes return to baseline in C57BL/6 J mice with obesity. However, genetic diversity significantly impacts this response. A period of weight loss does not provide lasting benefits after weight regain, and weight cycling is detrimental and associated with hyperinsulinemia and elevated basal insulin secretion.

Indexed as

Genetic VariationInsulin ResistanceMice, Inbred C57BLObesityAdipose TissueAnimalsBody CompositionDiet, High-FatDiet, WesternDisease Models, AnimalLiverMaleMiceWeight GainWeight Loss

Identifiers

PMID38961153
PMCPMC11281900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.