ArticleScientific reports2024
Blood-brain barrier integrity is linked to cognitive function, but not to cerebral arterial pulsatility, among elderly.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Quantifying Cardiac, Respiratory, and Low Frequency Components of CSF Motion From fMRI Inflow Effects.Magnetic resonance in medicine · 2026Article
- Biomedical Materials and Fabrication Methods for Construction of In Vitro Neurovascular Unit Models.Materials (Basel, Switzerland) · 2026Review
- Quantitative assessment of flow between cerebrospinal and interstitial fluid compartments in humans.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Modulation of the immunological and neuroinflammatory microenvironment in older people with multiple sclerosis.Frontiers in immunology · 2026Review
- Evaluating dopamine D2 receptor gene polymorphisms and peripheral inflammatory cytokines in ICU delirium: a two-stage exploratory observational study.Frontiers in medicine · 2026Article
- Regional blood-brain barrier dysfunction maps to lower performance in cognitive ageing.Brain communications · 2026Article
- The missing link: TNF-α as a unifying mechanism in methamphetamine-induced neuronal dysfunction and blood-brain barrier compromise.Journal of neuroimmunology · 2025Review
- Early-life gut microbiome maturity regulates blood-brain barrier and cognitive development.Gut microbes · 2025Article
- Imaging markers of neuroinflammation in aging and Alzheimer's disease and related dementia: A comprehensive review.Neuroscience and biobehavioral reviews · 2025Review
- Acute radiation-induced brain injury in patients with glioma and the construction of a clinical prediction model: a cohort study.Translational cancer research · 2025Article
- MRI contrast accumulation in features of cerebral small vessel disease: blood-brain barrier dysfunction or elevated vascular density?Fluids and barriers of the CNS · 2025Article
- Association between carotid artery hemodynamics and neurovascular coupling in cerebral small vessel disease: an exploratory study.Frontiers in aging neuroscience · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Blood-brain barrier (BBB) disruption may contribute to cognitive decline, but questions remain whether this association is more pronounced for certain brain regions, such as the hippocampus, or represents a whole-brain mechanism. Further, whether human BBB leakage is triggered by excessive vascular pulsatility, as suggested by animal studies, remains unknown. In a prospective cohort (N = 50; 68-84 years), we used contrast-enhanced MRI to estimate the permeability-surface area product (PS) and fractional plasma volume (
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Registered trials
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