Evidence map›Paper›PMID 38960966›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2024

Cancer-related cognitive impairment in older adults with acute myeloid leukemia treated with hypomethylating agents and venetoclax chemotherapy: a longitudinal descriptive study.

Ya-Ning Chan, Youngmin Cho, Rachel Hirschey, Aaron Piepmeier, Catherine M Bender, Ruth A Anderson, Matthew C Foster, Ashley Leak Bryant

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In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ya-Ning ChanDepartment of Population Health Sciences, Duke University, Durham, NC, USA. ya-ning.chan@duke.edu.ORCID http://orcid.org/0000-0002-7045-2892
Youngmin ChoSchool of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-7829-8634
Rachel HirscheySchool of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-8358-0650
Aaron PiepmeierDepartment of Exercise Science, Elon University, Elon, NC, USA.ORCID http://orcid.org/0000-0001-5813-0260
Catherine M BenderSchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Ruth A AndersonSchool of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Matthew C FosterLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ashley Leak BryantSchool of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-1178-1781

Funding

Physical activity intervention co-created and pilot tested with African American Colorectal Cancer SurvivorsK23MD015719 · NIMHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HIRSCHEY, RACHEL · 2021 to 2025
$795k
A Nurse-Led Palliative and Supportive Care Intervention for Newly Diagnosed Adults with Acute Myeloid LeukemiaR34NR019131 · NINR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BRYANT, ASHLEY LEAK · 2021 to 2022
$389k
Alpha Alpha Chapter, Sigma Theta Tau International Honor Society of Nursing Research GrantAmerican Cancer Society 134332-DSCN-20-076-01-SCNNIMHD NIH HHS K23 MD015719NIMHD NIH HHS K23 MD015719-01NINR NIH HHS R34 NR019131NINR NIH HHS R34NR019131School of Nursing, University of North Carolina at Chapel Hill, United States Arthur C. Maimon Doctoral Student Research Award (2020-2021)
6 · The paper itself

Abstract

purposeTo explore cancer-related cognitive impairment (CRCI) in older adults with acute myeloid leukemia (AML) receiving venetoclax in combination with hypomethylating agents or low-dose cytarabine chemotherapy.

methodsThis study is a longitudinal, qualitative descriptive study. Participants were recruited using purposive sampling. Semi-structured interviews were conducted among 11 older adults with AML at cycle 2, cycle 4, and cycle 7 of chemotherapy. An early end-of-study interview was conducted for those who changed treatment plans during the study follow-up.

resultsA total of 22 transcripts were included for thematic analysis. Four themes emerged: (1) CRCI experiences, (2) impact of CRCI, (3) CRCI coping strategies, and (4) perceived CRCI-related factors. Older adults with AML experienced challenges in memory, language, and attention both intermittently and daily. These cognitive changes impacted their emotion, daily activities, social connection, and their caregivers' responsibilities. Hence, these older adults with AML developed problem-solving and emotional coping strategies to cope with CRCI. Older adults with AML also identified demographic, physiology/clinical, psychological, and other factors that might contribute to CRCI.

conclusionThis study offers important insight for clinicians to understand how older adults with AML experience CRCI and how it impacts their daily routines. It indicates that clinicians should ask patients about their experience with cognitive changes at each encounter to provide support or coping strategies as needed to prevent CRCI from further hindering their quality of life.

Indexed as

Bridged Bicyclo Compounds, HeterocyclicLeukemia, Myeloid, AcuteSulfonamidesAdaptation, PsychologicalAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsCognitive DysfunctionCytarabineFemaleHumansLongitudinal StudiesMaleMiddle AgedQualitative ResearchBridged Bicyclo Compounds, HeterocyclicCytarabineSulfonamidesvenetoclaxAcute myeloid leukemiaCancer-related cognitive impairmentLongitudinal qualitative studyOlder adultsSemi-structured interview

Identifiers

PMID38960966
PMCPMC11311204

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.