Evidence map›Paper›PMID 38960961›Full record

ArticleBulletin of experimental biology and medicine2024

Effect of Short Peptides of Pregnancy-Specific β1-Glycoprotein on Differentiation of Human Regulatory T Cells In Vitro and on Their Cytokine Profile.

V P Timganova, M S Bochkova, K Yu Shardina, M B Rayev, A V Lyubimov, S A Zamorina

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

V P TimganovaInstitute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences - Branch of Perm State Research Center, Ural Branch of the Russian Academy of Sciences, Perm, Russia. timganovavp@gmail.com.
M S BochkovaInstitute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences - Branch of Perm State Research Center, Ural Branch of the Russian Academy of Sciences, Perm, Russia.
K Yu ShardinaInstitute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences - Branch of Perm State Research Center, Ural Branch of the Russian Academy of Sciences, Perm, Russia.
M B RayevInstitute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences - Branch of Perm State Research Center, Ural Branch of the Russian Academy of Sciences, Perm, Russia.
A V Lyubimov"Imbiocom" LLC, Perm, Russia.
S A ZamorinaInstitute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences - Branch of Perm State Research Center, Ural Branch of the Russian Academy of Sciences, Perm, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pregnancy-specific β1-glycoprotein (PSG), one of the most important proteins of pregnancy, has a pronounced immunosuppressive effect. Short peptides of PSG, the so-called SLiMs (short linear motifs), are promising molecules for mild immunosuppression. We studied in vitro effect of short PSG peptides (YACS, YQCE, YVCS, and YECE) on differentiation and cytokine profile of human T-regulatory lymphocytes (Treg). T helpers isolated from the peripheral blood and polarized into the Treg phenotype with a T-cell activator (anti-CD2/3/28) and the cytokines IL-2 and transforming grown factor β (TGFβ) were used. PSG peptides were shown to have no direct modulatory effect on Treg differentiation in a culture of CD4+ cells polarized to the Treg phenotype. At the same time, PSG peptides had no effect on the viability and number of CD4

Indexed as

Cell DifferentiationCytokinesPregnancy-Specific beta 1-GlycoproteinsT-Lymphocytes, RegulatoryCells, CulturedFemaleHumansInterleukin-2PeptidesPregnancyCytokinesInterleukin-2PeptidesPregnancy-Specific beta 1-GlycoproteinscytokinesIFNγpeptidespregnancy-specific β1-glycoproteinT-regulatory cells

Identifiers

PMID38960961

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.