Evidence map›Paper›PMID 38960916›Full record

ArticleAmino acids2024

PEGylation renders carnosine resistant to hydrolysis by serum carnosinase and increases renal carnosine levels.

Shiqi Zhang, Guang Yang, Qinqin Zhang, Yuying Fan, Mingna Tang, Liuhai Shen, Dongchun Zhu, Guiyang Zhang, Benito Yard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Amino acids, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shiqi Zhang *Department of Endocrinology, The first affiliated hospital of Anhui Medical University, Hefei, 230022, China. zhangshiqi@ahmu.edu.cn.ORCID http://orcid.org/0000-0002-2120-1544
Guang Yang *Department of Endocrinology, The first affiliated hospital of Anhui Medical University, Hefei, 230022, China.ORCID http://orcid.org/0000-0002-3586-6176
Qinqin ZhangDepartment of Endocrinology, The first affiliated hospital of Anhui Medical University, Hefei, 230022, China.
Yuying FanDepartment of Endocrinology, The first affiliated hospital of Anhui Medical University, Hefei, 230022, China.
Mingna TangDepartment of Endocrinology, The first affiliated hospital of Anhui Medical University, Hefei, 230022, China.
Liuhai ShenDepartment of Nuclear Medicine, Provincial Peoplès Hospital, Anhui No. 2, Hefei, 230041, China.
Dongchun ZhuDepartment of Pharmacy, The first affiliated hospital of Anhui Medical University, Hefei, 230022, China.
Guiyang ZhangDepartment of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, China.
Benito YardVth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Center Mannheim, University of Heidelberg, 68167, Mannheim, Germany.

Funding

National Natural Science Foundation of China 81900746
6 · The paper itself

Abstract

Carnosine's protective effect in rodent models of glycoxidative stress have provided a rational for translation of these findings in therapeutic concepts in patient with diabetic kidney disease. In contrast to rodents however, carnosine is rapidly degraded by the carnosinase-1 enzyme. To overcome this hurdle, we sought to protect hydrolysis of carnosine by conjugation to Methoxypolyethylene glycol amine (mPEG-NH

Indexed as

CarnosineDipeptidasesKidneyPolyethylene GlycolsAnimalsHumansHydrolysisMaleMiceaminoacyl-histidine dipeptidaseCarnosineDipeptidasesmonomethoxypolyethylene glycolPolyethylene GlycolsDiabetic nephropathyL-carnosinePEGylated carnosinePharmacokinetics

Identifiers

PMID38960916
PMCPMC11222247

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.