Evidence map›Paper›PMID 38960886›Full record

ArticleJournal of gastric cancer2024

Diffuse-Type Histology Is Prognostic for All Siewert Types of Gastroesophageal Adenocarcinoma.

Kelly M Mahuron, Kevin M Sullivan, Matthew C Hernandez, Yi-Jen Chen, Joseph Chao, Laleh G Melstrom, I Benjamin Paz, Jae Yul Kim, Rifat Mannan, James L Lin and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastric cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kelly M MahuronDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.ORCID 0000-0002-2544-5191
Kevin M SullivanDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.ORCID 0000-0001-7455-2308
Matthew C HernandezDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.
Yi-Jen ChenDepartment of Radiation Oncology, City of Hope National Medical Center, Duarte, CA, USA.
Joseph ChaoDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.
Laleh G MelstromDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.ORCID 0000-0001-6279-7981
I Benjamin PazDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.ORCID 0000-0002-8657-9011
Jae Yul KimDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.
Rifat MannanDivision of Thoracic Surgery, Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.
James L LinDepartment of Pathology, City of Hope National Medical Center, Duarte, CA, USA.
Yuman FongDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.ORCID 0000-0002-8934-9959
Yanghee WooDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.ORCID 0000-0002-6676-0593

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
Department of Surgery, Start-up GrantNCI NIH HHS P30 CA033572SU2C Gastric Cancer Interception Award SU2C-AACR-30-20-237459
6 · The paper itself

Abstract

purposeThe optimal treatment for gastroesophageal junction adenocarcinoma (GEJA) remains controversial. We evaluated the treatment patterns and outcomes of patients with locally advanced GEJA according to the histological type. MATERIALS AND

methodsWe conducted a single-institution retrospective cohort study of patients with locally advanced GEJA who underwent curative-intent surgical resection between 2010 and 2020. Perioperative therapies as well as clinicopathologic, surgical, and survival data were collected. The results of endoscopy and histopathological examinations were assessed for Siewert and Lauren classifications.

resultsAmong the 58 patients included in this study, 44 (76%) were clinical stage III, and all received neoadjuvant therapy (72% chemoradiation, 41% chemotherapy, 14% both chemoradiation and chemotherapy). Tumor locations were evenly distributed by Siewert Classification (33% Siewert-I, 40% Siewert-II, and 28% Siewert-III). Esophagogastrectomy (EG) was performed for 47 (81%) patients and total gastrectomy (TG) for 11 (19%) patients. All TG patients received D2 lymphadenectomy compared to 10 (21%) EG patients. Histopathological examination showed the presence of 64% intestinal-type and 36% diffuse-type histology. The frequencies of diffuse-type histology were similar among Siewert groups (37% Siewert-I, 36% Siewert-II, and 33% Siewert-III). Regardless of Siewert type and compared to intestinal-type, diffuse histology was associated with increased intraabdominal recurrence rates (P=0.03) and decreased overall survival (hazard ratio, 2.33; P=0.02). With a median follow-up of 31.2 months, 29 (50%) patients had a recurrence, and the median overall survival was 50.5 months.

conclusionsPresent in equal proportions among Siewert types of esophageal and gastric cancer, a diffuse-type histology was associated with high intraabdominal recurrence rates and poor survival. Histopathological evaluation should be considered in addition to anatomic location in the determination of multimodal GEJA treatment strategies.

Indexed as

AdenocarcinomaEsophageal NeoplasmsEsophagogastric JunctionStomach NeoplasmsAdultAgedAged, 80 and overEsophagectomyFemaleGastrectomyHumansMaleMiddle AgedPrognosisRetrospective StudiesSurvival RateEsophageal cancerEsophagogastric junction adenocarcinomaGastric cancerHistology evaluationSiewert-Stein classification

Identifiers

PMID38960886
PMCPMC11224723

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.