Evidence map›Paper›PMID 38960881›Full record

Trial reportThe British journal of surgery2024

Multicentre randomized clinical trial on robot-assisted versus video-assisted thoracoscopic oesophagectomy (REVATE trial).

Yin-Kai Chao, Zhigang Li, Hongjing Jiang, Yu-Wen Wen, Chen-Hung Chiu, Bin Li, Xiaobin Shang, Tuan-Jen Fang, Yang Yang, Jie Yue and 3 more

2 registry-linked trialsAbstract readRandomized Controlled TrialMulticenter StudyComparative Study
In one paragraph

Trial report in The British journal of surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03713749 naunknown statusnot on this map

Robotic-assisted Esophagectomy vs. Video-Assisted Thoracoscopic Esophagectomy(REVATE) : a Multicenter Open-label Randomized Controlled Trial

TypeinterventionalSponsorChang Gung Memorial HospitalRan2018 to 2022Enrolled212ConditionsEsophageal Squamous Cell CarcinomaArmsRobot esophagectomy (RE)
NCT06897501 narecruitingnot on this mapstarted 2025, after this paper: background citation

Incidence of Postoperative Vocal Cord Palsy Between Double-lumen Endobronchial Tube and Bronchial Blocker for Robot-assisted Esophagectomy: a Multicenter Randomized Controlled Trial

TypeinterventionalSponsorSamsung Medical CenterRan2025 to 2026Enrolled202ConditionsOne Lung Ventillation (OLV)Armsbronchial blocker, double-lumen endobronchial tube
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yin-Kai ChaoDivision of Thoracic Surgery, Chang Gung Memorial Hospital-Linkou, Chang Gung University, Taoyuan, Taiwan.ORCID 0000-0001-8649-8783
Zhigang LiDivision of Thoracic Surgery, Shanghai Chest Hospital, Shanghai, China.
Hongjing JiangDepartment of Minimally Invasive Oesophageal Surgery, Key Laboratory of Prevention and Therapy, National Clinical Research Centre of Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Yu-Wen WenDivision of Thoracic Surgery, Chang Gung Memorial Hospital-Linkou, Chang Gung University, Taoyuan, Taiwan.
Chen-Hung ChiuDivision of Thoracic Surgery, Chang Gung Memorial Hospital-Linkou, Chang Gung University, Taoyuan, Taiwan.
Bin LiDivision of Thoracic Surgery, Shanghai Chest Hospital, Shanghai, China.
Xiaobin ShangDepartment of Minimally Invasive Oesophageal Surgery, Key Laboratory of Prevention and Therapy, National Clinical Research Centre of Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Tuan-Jen FangDepartment of Otorhinolaryngology Head and Neck Surgery, Chang Gung Memorial Hospital-Linkou, Chang Gung University, Taoyuan, Taiwan.
Yang YangDivision of Thoracic Surgery, Shanghai Chest Hospital, Shanghai, China.ORCID 0000-0003-2866-4215
Jie YueDepartment of Minimally Invasive Oesophageal Surgery, Key Laboratory of Prevention and Therapy, National Clinical Research Centre of Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Xiaobin ZhangDivision of Thoracic Surgery, Shanghai Chest Hospital, Shanghai, China.
Chen ZhangDepartment of Minimally Invasive Oesophageal Surgery, Key Laboratory of Prevention and Therapy, National Clinical Research Centre of Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Yun-Hen LiuDivision of Thoracic Surgery, Chang Gung Memorial Hospital-Linkou, Chang Gung University, Taoyuan, Taiwan.

Funding

Chang Gung Memorial Hospital, Taiwan CMRPG3H0951Intuitive SurgicalmePrecision Treatment Technology for Oncology Surgery programShanghai Academic/Technology Research Leader, China 22XD1402900Tianjin Medical University Cancer Institute and Hospital, Tianjin, China ZLWKJZZL02
6 · The paper itself

Abstract

backgroundSurgery for oesophageal squamous cell carcinoma involves dissecting lymph nodes along the recurrent laryngeal nerve. This is technically challenging and injury to the recurrent laryngeal nerve may lead to vocal cord palsy, which increases the risk of pulmonary complications. The aim of this study was to compare the efficacy and safety of robot-assisted oesophagectomy (RAO) versus video-assisted thoracoscopic oesophagectomy (VAO) for dissection of lymph nodes along the left RLN.

methodsPatients with oesophageal squamous cell carcinoma who were scheduled for minimally invasive McKeown oesophagectomy were allocated randomly to RAO or VAO, stratified by centre. The primary endpoint was the success rate of left recurrent laryngeal nerve lymph node dissection. Success was defined as the removal of at least one lymph node without causing nerve damage lasting longer than 6 months. Secondary endpoints were perioperative and oncological outcomes.

resultsFrom June 2018 to March 2022, 212 patients from 3 centres in Asia were randomized, and 203 were included in the analysis (RAO group 103; VAO group 100). Successful left recurrent laryngeal nerve lymph node dissection was achieved in 88.3% of the RAO group and 69% of the VAO group (P < 0.001). The rate of removal of at least one lymph node according to pathology was 94.2% for the RAO and 86% for the VAO group (P = 0.051). At 1 week after surgery, the RAO group had a lower incidence of left recurrent laryngeal nerve palsy than the VAO group (20.4 versus 34%; P = 0.029); permanent recurrent laryngeal nerve palsy rates at 6 months were 5.8 and 20% respectively (P = 0.003). More mediastinal lymph nodes were dissected in the RAO group (median 16 (i.q.r. 12-22) versus 14 (10-20); P = 0.035). Postoperative complication rates were comparable between the two groups and there were no in-hospital deaths.

conclusionIn patients with oesophageal squamous cell carcinoma, RAO leads to more successful left recurrent laryngeal nerve lymph node dissection than VAO, including a lower rate of short- and long-term recurrent laryngeal nerve injury. Registration number: NCT03713749 (http://www.clinicaltrials.gov).

Indexed as

Esophageal NeoplasmsEsophagectomyLymph Node ExcisionRobotic Surgical ProceduresThoracic Surgery, Video-AssistedAdultAgedEsophageal Squamous Cell CarcinomaFemaleHumansMaleMiddle AgedPostoperative ComplicationsRecurrent Laryngeal NerveRecurrent Laryngeal Nerve InjuriesTreatment Outcome

Identifiers

PMID38960881
PMCPMC11221944

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.