Evidence map›Paper›PMID 38960722›Full record

ArticleAmerican journal of epidemiology2025

Prevalence and correlates of diagnosed and probable polycystic ovary syndrome (PCOS) in a cohort of parous women.

Wei Perng, Victoria W Fitz, Kyle Salmon, Marie-France Hivert, Maryam Kazemi, Sheryl L Rifas-Shiman, Jan Shifren, Emily Oken, Jorge E Chavarro

Abstract read
In one paragraph

Article in American journal of epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wei PerngDepartment of Epidemiology, Colorado School of Public Health, Aurora, CO 80045, United States.ORCID 0000-0001-8552-6850
Victoria W FitzDepartment of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA 02114, United States.
Kyle SalmonDepartment of Epidemiology, Colorado School of Public Health, Aurora, CO 80045, United States.
Marie-France HivertDivision of Chronic Disease Research across the Lifecourse (CORaL), Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Healthcare Institute, Boston, MA 02215, United States.
Maryam KazemiDepartment of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA 02115, United States.
Sheryl L Rifas-ShimanDivision of Chronic Disease Research across the Lifecourse (CORaL), Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Healthcare Institute, Boston, MA 02215, United States.
Jan ShifrenDepartment of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA 02114, United States.
Emily OkenDivision of Chronic Disease Research across the Lifecourse (CORaL), Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Healthcare Institute, Boston, MA 02215, United States.
Jorge E ChavarroDepartment of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA 02115, United States.ORCID 0000-0002-4436-9630

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
A lifecourse approach to women's mental health: from fertility to perimenopauseR01HD096032 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI CHAVARRO, JORGE EDUARDO, OKEN, EMILY · 2019 to 2023
$3.6M
Maintain and Enrich Resource Infrastructure for Project Viva: a pre-birth cohort with follow up into adolescenceR24ES030894 · NIEHS · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2020 to 2024
$2.0M
NICHD NIH HHS R01 HD096032NIDDK NIH HHS P30 DK048520NIEHS NIH HHS R24 ES030894NIH HHS R01HD096032
6 · The paper itself

Abstract

Correlates of diagnosed and probable polycystic ovary syndrome (PCOS) among parous women were assessed in this study. A total of 557 women were recruited from multi-specialty clinics in eastern Massachusetts. The women were categorized as being diagnosed with PCOS based on medical records and self-reported clinician-diagnoses. A category of "probable PCOS" was created for women without a diagnosis but with ≥ 2 of the following: ovulatory dysfunction (cycle length < 21 or ≥ 35 days), hyperandrogenism (free testosterone concentration > 75th percentile), or elevated anti-Müllerian hormone (AMH) concentration (> 75th percentile). The remaining participants were placed in the "no PCOS" category, and characteristics were compared across groups. Of the total cohort, 9.7% had diagnosed and 9.2% had probable PCOS. The frequency of irregular cycles was similar for diagnosed and probable PCOS. Free testosterone and AMH levels were higher in women with probable than with diagnosed PCOS. Frequency of irregular cycles and both hormones were higher for the 2 PCOS groups vs the no PCOS group. Obesity prevalence for diagnosed PCOS was twice that of probable PCOS (43.9% vs 19.6%), yet the 2 groups had similar HbA1c and adiponectin values. Women with probable PCOS are leaner but have comparable glycemic traits to those with a formal diagnosis, highlighting the importance of assessing biochemical profiles among women with irregular cycles, even in the absence of overweight/obesity.

Indexed as

Polycystic Ovary SyndromeAdiponectinAdultAnti-Mullerian HormoneBody Mass IndexCohort StudiesFemaleGlycated HemoglobinHumansHyperandrogenismMassachusettsObesityPrevalenceTestosteroneYoung AdultAdiponectinAnti-Mullerian HormoneGlycated HemoglobinTestosteroneanti-Mullerian hormonecohorthyperandrogenismirregular menstrual cyclesoligo-anovulationparouspolycystic ovary syndrome (PCOS)Rotterdam criteria

Identifiers

PMID38960722
PMCPMC11735947

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.