Evidence map›Paper›PMID 38960626›Full record

Trial reportJournal of psychiatry & neuroscience : JPN

Cerebellar network alterations in adult attention-deficit/hyperactivity disorder.

Salla Parkkinen, Joaquim Radua, Derek S Andrews, Declan Murphy, Flavio Dell'Acqua, Valeria Parlatini

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03709940 (Brain Connectivity in Attention Deficit Hyperactivity Disorder), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03709940 nacompletednot on this map

Brain Connectivity in Attention Deficit Hyperactivity Disorder (ADHD): a Biomarker to Predict Treatment Response

TypeinterventionalSponsorKing's College LondonRan2013 to 2016Enrolled60ConditionsAttention Deficit Hyperactivity Disorder (ADHD)ArmsMPH
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Involvement of the Cerebellar Peduncles inInternational journal of molecular sciences · 2025
    Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Salla ParkkinenFrom the Institute of Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK (Parkkinen, Andrews, Murphy, Dell'Acqua, Parlatini); the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK (Parkkinen, Murphy, Dell'Acqua, Parlatini); the Institut d'Investigacions Biomèdiques August Pi i Sunyer, CIBERSAM, Instituto de Salud Carlos III, University of Barcelona, Barcelona, Spain (Radua); the Department of Psychiatry and Behavioral Sciences, The MIND Institute, University of California, Davis, Sacramento, CA, USA (Andrews); the Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK (Dell'Acqua); the NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK (Dell'Acqua); the School of Psychology, University of Southampton, Southampton, UK (Parlatini); the Solent NHS Trust, Southampton, UK (Parlatini).
Joaquim RaduaFrom the Institute of Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK (Parkkinen, Andrews, Murphy, Dell'Acqua, Parlatini); the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK (Parkkinen, Murphy, Dell'Acqua, Parlatini); the Institut d'Investigacions Biomèdiques August Pi i Sunyer, CIBERSAM, Instituto de Salud Carlos III, University of Barcelona, Barcelona, Spain (Radua); the Department of Psychiatry and Behavioral Sciences, The MIND Institute, University of California, Davis, Sacramento, CA, USA (Andrews); the Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK (Dell'Acqua); the NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK (Dell'Acqua); the School of Psychology, University of Southampton, Southampton, UK (Parlatini); the Solent NHS Trust, Southampton, UK (Parlatini).
Derek S AndrewsFrom the Institute of Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK (Parkkinen, Andrews, Murphy, Dell'Acqua, Parlatini); the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK (Parkkinen, Murphy, Dell'Acqua, Parlatini); the Institut d'Investigacions Biomèdiques August Pi i Sunyer, CIBERSAM, Instituto de Salud Carlos III, University of Barcelona, Barcelona, Spain (Radua); the Department of Psychiatry and Behavioral Sciences, The MIND Institute, University of California, Davis, Sacramento, CA, USA (Andrews); the Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK (Dell'Acqua); the NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK (Dell'Acqua); the School of Psychology, University of Southampton, Southampton, UK (Parlatini); the Solent NHS Trust, Southampton, UK (Parlatini).
Declan MurphyFrom the Institute of Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK (Parkkinen, Andrews, Murphy, Dell'Acqua, Parlatini); the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK (Parkkinen, Murphy, Dell'Acqua, Parlatini); the Institut d'Investigacions Biomèdiques August Pi i Sunyer, CIBERSAM, Instituto de Salud Carlos III, University of Barcelona, Barcelona, Spain (Radua); the Department of Psychiatry and Behavioral Sciences, The MIND Institute, University of California, Davis, Sacramento, CA, USA (Andrews); the Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK (Dell'Acqua); the NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK (Dell'Acqua); the School of Psychology, University of Southampton, Southampton, UK (Parlatini); the Solent NHS Trust, Southampton, UK (Parlatini).
Flavio Dell'AcquaFrom the Institute of Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK (Parkkinen, Andrews, Murphy, Dell'Acqua, Parlatini); the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK (Parkkinen, Murphy, Dell'Acqua, Parlatini); the Institut d'Investigacions Biomèdiques August Pi i Sunyer, CIBERSAM, Instituto de Salud Carlos III, University of Barcelona, Barcelona, Spain (Radua); the Department of Psychiatry and Behavioral Sciences, The MIND Institute, University of California, Davis, Sacramento, CA, USA (Andrews); the Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK (Dell'Acqua); the NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK (Dell'Acqua); the School of Psychology, University of Southampton, Southampton, UK (Parlatini); the Solent NHS Trust, Southampton, UK (Parlatini).
Valeria ParlatiniFrom the Institute of Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK (Parkkinen, Andrews, Murphy, Dell'Acqua, Parlatini); the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK (Parkkinen, Murphy, Dell'Acqua, Parlatini); the Institut d'Investigacions Biomèdiques August Pi i Sunyer, CIBERSAM, Instituto de Salud Carlos III, University of Barcelona, Barcelona, Spain (Radua); the Department of Psychiatry and Behavioral Sciences, The MIND Institute, University of California, Davis, Sacramento, CA, USA (Andrews); the Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK (Dell'Acqua); the NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK (Dell'Acqua); the School of Psychology, University of Southampton, Southampton, UK (Parlatini); the Solent NHS Trust, Southampton, UK (Parlatini) valeria.parlatini@kcl.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAttention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental condition that often persists into adulthood. Underlying alterations in brain connectivity have been identified but some relevant connections, such as the middle, superior, and inferior cerebellar peduncles (MCP, SCP, and ICP, respectively), have remained largely unexplored; thus, we sought to investigate whether the cerebellar peduncles contribute to ADHD pathophysiology among adults.

methodsWe applied diffusion-weighted spherical deconvolution tractography to dissect the cerebellar peduncles of male adults with ADHD (including those who did or did not respond to methylphenidate, based on at least 30% symptom improvement at 2 months) and controls. We investigated differences in tract metrics between controls and the whole ADHD sample and between controls and treatment-response groups using sensitivity analyses. Finally, we analyzed the association between the tract metrics and cliniconeuropsychological profiles.

resultsWe included 60 participants with ADHD (including 42 treatment responders and 18 nonresponders) and 20 control participants. In the whole ADHD sample, MCP fractional anisotropy (FA; LIMITATIONS: This study included only male adults with ADHD. Further research needs to investigate potential sex- and development-related differences.

conclusionThese results support the role of the cerebellar networks, especially of the MCP, in adult ADHD pathophysiology and should encourage further investigation. CLINICAL

trial registrationNCT03709940.

Indexed as

Attention Deficit Disorder with HyperactivityCerebellumDiffusion Tensor ImagingMethylphenidateAdultAnisotropyCase-Control StudiesCentral Nervous System StimulantsHumansMaleNerve NetNeural PathwaysWhite MatterYoung AdultCentral Nervous System StimulantsMethylphenidate

Identifiers

PMID38960626
PMCPMC11230668

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.