Evidence map›Paper›PMID 38960622›Full record

ArticleLife science alliance2024

Repression of SMAD3 by STAT3 and c-Ski induces conventional dendritic cell differentiation.

Jeong-Hwan Yoon, Eunjin Bae, Yasuo Nagafuchi, Katsuko Sudo, Jin Soo Han, Seok Hee Park, Susumu Nakae, Tadashi Yamashita, Ji Hyeon Ju, Isao Matsumoto and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jeong-Hwan YoonBiomedical Research Institute, Kyungpook National University Hospital, Daegu, Republic of Korea.ORCID 0000-0001-6445-1036
Eunjin BaeDepartment of Molecular Pathology, Tokyo Medical University, Tokyo, Japan.ORCID 0000-0001-6526-6369
Yasuo NagafuchiDepartment of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Katsuko SudoAnimal Research Center, Tokyo Medical University, Tokyo, Japan.ORCID 0000-0002-5286-7648
Jin Soo HanInstitute for the 3Rs, Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.ORCID 0000-0003-2136-1932
Seok Hee ParkDepartment of Biological Sciences, Sungkyunkwan University, Suwon, Republic of Korea.
Susumu NakaeGraduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima, Japan.
Tadashi YamashitaLaboratory of Veterinary Biochemistry, Azabu University School of Veterinary Medicine, Sagamihara, Japan.
Ji Hyeon JuDepartment of Rheumatology, Catholic University of Korea, Seoul St. Mary Hospital, Seoul, Republic of Korea.
Isao MatsumotoDepartment of Internal Medicine, University of Tsukuba, Tsukuba, Japan.
Takayuki SumidaDepartment of Internal Medicine, University of Tsukuba, Tsukuba, Japan.
Keiji MiyazawaDepartments of Biochemistry, University of Yamanashi, Yamanashi, Japan.ORCID 0000-0002-7835-7718
Mitsuyasu KatoDepartment of Experimental Pathology, Graduate School of Comprehensive Human Sciences and Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Masahiko KurodaDepartment of Molecular Pathology, Tokyo Medical University, Tokyo, Japan.
In-Kyu LeeBiomedical Research Institute, Kyungpook National University Hospital, Daegu, Republic of Korea.
Keishi FujioDepartment of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Mizuko MamuraBiomedical Research Institute, Kyungpook National University Hospital, Daegu, Republic of Korea mikoeyo@gmail.com.ORCID 0000-0003-4531-0144

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A pleiotropic immunoregulatory cytokine, TGF-β, signals via the receptor-regulated SMADs: SMAD2 and SMAD3, which are constitutively expressed in normal cells. Here, we show that selective repression of SMAD3 induces cDC differentiation from the CD115

Indexed as

Cell DifferentiationDendritic CellsDNA-Binding ProteinsProto-Oncogene ProteinsSmad3 ProteinSTAT3 Transcription FactorAnimalsfms-Like Tyrosine Kinase 3Inhibitor of Differentiation Protein 2Interferon Regulatory Factor-4Interferon Regulatory FactorsMiceMice, Inbred C57BLMice, KnockoutPhosphorylationSignal TransductionDNA-Binding ProteinsFlt3 protein, mousefms-Like Tyrosine Kinase 3Idb2 protein, mouseInhibitor of Differentiation Protein 2Interferon Regulatory Factor-4Interferon Regulatory FactorsProto-Oncogene ProteinsSki protein, mouseSmad2 ProteinSmad2 protein, mouseSmad3 ProteinSmad3 protein, mouseStat3 protein, mouseSTAT3 Transcription Factor

Identifiers

PMID38960622
PMCPMC11222659

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.