ArticleBMJ open2024
Predictive value of the dynamics of absolute lymphocyte counts for 90-day mortality in ICU sepsis patients: a retrospective big data study.
Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The trial behind it
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Who cites it
5 citing papers in PubMed.
- Decreased CD3 + CD4+ T lymphocyte count predicts 28-day all-cause mortality in severe AECOPD patients admitted to the ICU: a retrospective cohort study.Scientific reports · 2026Article
- Immune dysregulation through longitudinal lymphocyte trajectories and their clinical determinants in hospitalized COVID-19 patients.Intensive care medicine experimental · 2026Article
- Systematic review, meta-analysis, and meta-regression of the association of serial leukocyte counts in critically ill patients and mortality.Annals of intensive care · 2026Article
- Enhancing prognostic accuracy in sepsis: a modified SOFA score incorporating lymphocyte count as an immune function marker.Frontiers in cellular and infection microbiology · 2025Article
- Impact of absolute lymphocyte count upon admission to ICU on 28-day mortality in sepsis patients in ICU.Frontiers in immunology · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe objective of the study was to assess the clinical predictive value of the dynamics of absolute lymphocyte count (ALC) for 90-day all-cause mortality in sepsis patients in intensive care unit (ICU).
designRetrospective cohort study using big data.
settingThis study was conducted using the Medical Information Mart for Intensive Care IV database V.2.0 database. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome was 90-day all-cause mortality.
participantsPatients were included if they were diagnosed with sepsis on the first day of ICU admission. Exclusion criteria were ICU stay under 24 hours; the absence of lymphocyte count on the first day; extremely high lymphocyte count (>10×10
resultsThe ALC in the non-survivors group was lower on days 1, 3, 5 and 7 after admission (p<0.001). The ALC on day 7 had the highest area under the curve (AUC) value for predicting 90-day mortality. The cut-off value of ALC on day 7 was 1.0×10
conclusionsDynamic changes of ALC are closely associated with 90-day all-cause mortality in sepsis patients. Furthermore, the ALC on day 7 after admission is a better independent predictor of 90-day mortality in sepsis patients, especially in severely ill or young sepsis patients.
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