Evidence map›Paper›PMID 38960129›Full record

ArticleMolecular metabolism2024

NCLX controls hepatic mitochondrial Ca

Mahmoud Taha, Essam A Assali, Tsipi Ben-Kasus Nissim, Grace E Stutzmann, Orian S Shirihai, Michal Hershfinkel, Israel Sekler

Abstract read
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In one paragraph

Article in Molecular metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Mitochondrial Calcium Signaling in Hepatocyte Health and Disease.Cold Spring Harbor perspectives in biology · 2026
    Review
  3. Article
  4. Mitochondrial CaJournal of cellular physiology · 2025
    Review
  5. TMEM65 functions as the mitochondrial NaNature cell biology · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mahmoud TahaDepartment of Physiology and Cell Biology, Ben Gurion University, Beer-Sheva 8410501, Israel.
Essam A AssaliDepartment of Physiology and Cell Biology, Ben Gurion University, Beer-Sheva 8410501, Israel; Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA. Electronic address: essam@post.bgu.ac.il.
Tsipi Ben-Kasus NissimDepartment of Physiology and Cell Biology, Ben Gurion University, Beer-Sheva 8410501, Israel.
Grace E StutzmannCenter for Neurodegenerative Disease and Therapeutics, Rosalind Franklin University of Medicine and Science. North Chicago, IL 60064, USA.
Orian S ShirihaiDepartment of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, 90095, USA.
Michal HershfinkelDepartment of Physiology and Cell Biology, Ben Gurion University, Beer-Sheva 8410501, Israel.
Israel SeklerDepartment of Physiology and Cell Biology, Ben Gurion University, Beer-Sheva 8410501, Israel. Electronic address: sekler@bgu.ac.il.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveHepatic Ca

methodsPrimary mouse hepatocytes from both an AAV-mediated conditional hepatic-specific and a total mitochondrial Na

resultsAnalysis of Ca

conclusionsThe study findings demonstrate that NCLX acts as the primary Ca

Indexed as

CalciumCalcium SignalingGlucagonGluconeogenesisHepatocytesMice, KnockoutSodium-Calcium ExchangerAnimalsCells, CulturedGlucoseLiverMaleMiceMice, Inbred C57BLMitochondria, LiverVasopressinsCalciumGlucagonGlucoseSlc8b1protein, mouseSodium-Calcium ExchangerVasopressinsCalcium signalingGluconeogenesisHepatic calcium signalingMitocondrial calciumNCLX

Identifiers

PMID38960129
PMCPMC11325370

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.