Evidence map›Paper›PMID 38959991›Full record

ArticlePhysiology & behavior2024

Optical perturbation of Agtr1a-containing neurons and afferents within the caudal nucleus of the solitary tract modulates sodium intake.

Caitlin Baumer-Harrison, Sagar Patel, Karen A Scott, Eric G Krause, Annette D de Kloet

Abstract read
In one paragraph

Article in Physiology & behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Cardiac vagal motor neurons.Current opinion in neurobiology · 2025
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Caitlin Baumer-HarrisonDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, 32611, United States; Center for Integrative Cardiovascular and Metabolic Diseases, University of Florida, Gainesville, FL, 32611, United States; Center for Smell and Taste, University of Florida, Gainesville, FL, 32611, United States; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States. Electronic address: caitlin.baumer-harrison@pennmedicine.upenn.edu.
Sagar PatelDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, 32611, United States.
Karen A ScottCenter for Integrative Cardiovascular and Metabolic Diseases, University of Florida, Gainesville, FL, 32611, United States; Department of Pharmacodynamics, College of Pharmacy, University of Florida, 32611, United States; Neuroscience Institute, Georgia State University, Atlanta, GA, 30302, United States.
Eric G KrauseCenter for Integrative Cardiovascular and Metabolic Diseases, University of Florida, Gainesville, FL, 32611, United States; Department of Pharmacodynamics, College of Pharmacy, University of Florida, 32611, United States; Neuroscience Institute, Georgia State University, Atlanta, GA, 30302, United States.
Annette D de KloetDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, 32611, United States; Center for Integrative Cardiovascular and Metabolic Diseases, University of Florida, Gainesville, FL, 32611, United States; Center for Smell and Taste, University of Florida, Gainesville, FL, 32611, United States; Neuroscience Institute, Georgia State University, Atlanta, GA, 30302, United States.

Funding

Interrogating stress-relieving neural circuits to alleviate cardiovascular diseaseR35HL150750 · NHLBI · UNIVERSITY OF FLORIDA · PI Eric Gerald Krause · 2020 to 2026
$5.9M
Neurons expressing angiotensin type 2 receptors in the NTS as an access point for cardiovascular control.R01HL136595 · NHLBI · UNIVERSITY OF FLORIDA · PI COLIN SUMNERS, Annette Diane de Kloet · 2018 to 2026
$4.8M
Interrogating distinct angiotensin type-1 and type-2 receptor containing brain circuits to understand and alleviate hypertensionR01HL145028 · NHLBI · UNIVERSITY OF FLORIDA · PI DE KLOET, ANNETTE DIANE · 2019 to 2023
$1.9M
Training Program in Chemosensory ScienceT32DC015994 · NIDCD · UNIVERSITY OF FLORIDA · PI Daniel W Wesson · 2018 to 2026
$1.4M
Novel role of central AT2R in blood pressure regulationR00HL125805 · NHLBI · UNIVERSITY OF FLORIDA · PI DE KLOET, ANNETTE DIANE · 2016 to 2018
$746k
Novel role of central AT2R in blood pressure regulationK99HL125805 · NHLBI · UNIVERSITY OF FLORIDA · PI DE KLOET, ANNETTE DIANE · 2015 to 2016
$225k
Gustatory and interoceptive regulation of hypertensionF31HL162540 · NHLBI · UNIVERSITY OF FLORIDA · PI BAUMER HARRISON, CAITLIN MARIE · 2022 to 2023
$67k
NHLBI NIH HHS F31 HL162540NHLBI NIH HHS K99 HL125805NHLBI NIH HHS R00 HL125805NHLBI NIH HHS R01 HL136595NHLBI NIH HHS R01 HL145028NHLBI NIH HHS R35 HL150750NIDCD NIH HHS T32 DC015994
6 · The paper itself

Abstract

Angiotensin-II (Ang-II) production is driven by deviations in blood volume and osmolality, and serves the role of regulating blood pressure and fluid intake to maintain cardiovascular and hydromineral homeostasis. These actions are mediated by Ang-II acting on its type 1a receptor (AT1aR) within the central nervous system and periphery. Of relevance, AT1aR are expressed on sensory afferents responsible for conveying cardiovascular information to the nucleus of the solitary tract (NTS). We have previously determined that optical excitation of neurons and vagal afferents within the NTS that express AT1aR (referred to as NTS

Indexed as

NeuronsReceptor, Angiotensin, Type 1Solitary NucleusAnimalsDrinkingMaleNeurons, AfferentOptogeneticsSodium ChlorideReceptor, Angiotensin, Type 1Sodium ChlorideAng-IIAT1RBaroreceptorHydromineral balanceSodium intake

Identifiers

PMID38959991
PMCPMC11526814

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.