Evidence map›Paper›PMID 38959891›Full record

ArticleCell2024

The germline coordinates mitokine signaling.

Koning Shen, Jenni Durieux, Cesar G Mena, Brant M Webster, C Kimberly Tsui, Hanlin Zhang, Larry Joe, Kristen M Berendzen, Andrew Dillin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  7. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Koning ShenDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Jenni DurieuxDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Cesar G MenaDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Brant M WebsterDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
C Kimberly TsuiDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Hanlin ZhangDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Larry JoeDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Kristen M BerendzenWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Andrew DillinDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; The Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: dillin@berkeley.edu.

Funding

Neuroendocrine Coordination of Mitochondrial Stress Signaling and ProteostasisR01ES021667 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI DILLIN, ANDREW G · 2012 to 2023
$4.6M
The Perception of Mitochondrial Stress in Receiving CellsR37AG024365 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI DILLIN, ANDREW G · 2011 to 2020
$4.0M
The role of mitochondria-lysosome crosstalk in health and agingK99AG071935 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI SHEN, KONING · 2021 to 2022
$223k
Systemic Regulation of ER ProteostasisF32AG069388 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI TSUI, CHUNG YIN KIMBERLY · 2021 to 2023
$210k
Howard Hughes Medical InstituteNIA NIH HHS F32 AG069388NIA NIH HHS K99 AG071935NIA NIH HHS R37 AG024365NIEHS NIH HHS R01 ES021667
6 · The paper itself

Abstract

The ability of mitochondria to coordinate stress responses across tissues is critical for health. In C. elegans, neurons experiencing mitochondrial stress elicit an inter-tissue signaling pathway through the release of mitokine signals, such as serotonin or the Wnt ligand EGL-20, which activate the mitochondrial unfolded protein response (UPR

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsGerm CellsMitochondriaSignal TransductionUnfolded Protein ResponseAnimalsNeuronsSerotoninWnt ProteinsCaenorhabditis elegans ProteinsSerotoninWnt ProteinsagingC. elegansgermlinelipidsmitochondriamtUPRproteostasisstress response

Identifiers

PMID38959891
PMCPMC12261959

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.