ArticleCell reports. Medicine2024
Protection from environmental enteric dysfunction and growth improvement in malnourished newborns by amplification of secretory IgA.
Article in Cell reports. Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- The effect of mental training on muscle damage, stress, and immune response biomarkers in tennis athletes.BMC sports science, medicine & rehabilitation · 2026Article
- Enteropathy produced in mice by intergenerational transmission of small intestinal microbiota from undernourished children.Nature microbiology · 2026Article
- The effect of an 8-week Life Kinetics exercise program on salivary cortisol, alpha-amylase, and ımmunoglobulin-A in U14 female cross-country skiers.Frontiers in physiology · 2026Article
- Effects of intergenerational transmission of small intestinal bacteria cultured from stunted Bangladeshi children with enteropathy.bioRxiv : the preprint server for biology · 2025Article
- Review
- Protein undernutrition alters the colonic bacteriome, disrupts intestinal immune homeostasis, and impairs control ofFrontiers in nutrition · 2025Article
- Antibodies in breast milk: Pro-bodies designed for healthy newborn development.Immunological reviews · 2024Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental enteric dysfunction (EED) is a condition associated with malnutrition that can progress to malabsorption and villous atrophy. Severe EED results in linear growth stunting, slowed neurocognitive development, and unresponsiveness to oral vaccines. Prenatal exposure to malnutrition and breast feeding by malnourished mothers replicates EED. Pups are characterized by deprivation of secretory IgA (SIgA) and altered development of the gut immune system and microbiota. Extracellular ATP (eATP) released by microbiota limits T follicular helper (Tfh) cell activity and SIgA generation in Peyer's patches (PPs). Administration of a live biotherapeutic releasing the ATP-degrading enzyme apyrase to malnourished pups restores SIgA levels and ameliorates stunted growth. SIgA is instrumental in improving the growth and intestinal immune competence of mice while they are continuously fed a malnourished diet. The analysis of microbiota composition suggests that amplification of endogenous SIgA may exert a dominant function in correcting malnourishment dysbiosis and its consequences on host organisms, irrespective of the actual microbial ecology.
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