ArticleCell metabolism2024
Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities.
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Article in Cell metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.
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70citing papers in PubMed, 1 pooled it
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Who cites it
70 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Discovery of obesity genes through cross-ancestry analysis.Nature communications · 2025Pooled it
- Effects of obesity on brain health and cognition.Nature reviews. Neurology · 2026Review
- Co-occurrence patterns and related risk factors of type 2 diabetes mellitus and metabolic dysfunction-associated steatotic liver disease.Endocrine · 2026Article
- Systolic blood pressure variability as a risk factor for abdominal aortic aneurysm: a prospective cohort study with genomic and proteomic profiling.European journal of epidemiology · 2026Article
- Diet-Dependent Effects of Intracerebroventricular Maresin-1 on Hypothalamus of Rats.International journal of molecular sciences · 2026Article
- Socioeconomic Determinants Associated With Overweight and Obesity in Adults in Southern Tehran: A Cross-Sectional Study.Health science reports · 2026Article
- Polyphenols intake and expression of insulin signaling genes in adipose tissue of obese adults: a cross-sectional study.Scientific reports · 2026Article
- The impact of cumulative obesity and genetic susceptibility on biological aging in Chinese older adults.GeroScience · 2026Article
- Adherence to the Eatwell Guide and associations with markers of adiposity: a prospective analysis within the UK Biobank cohort.International journal of obesity (2005) · 2026Article
- Review
- The joint association of health-enhancing walking and healthful diet with central obesity: a longitudinal repeated-measures study.International journal of obesity (2005) · 2026Article
- Age at Appendectomy, Pneumonia/Influenza Risk, and The Role of Modifiable Risk-factor Profiles.Journal of epidemiology and global health · 2026Article
- Association of socioeconomic status and lifestyle factors with incident diabetes among individuals with prediabetes: a prospective cohort study from UK Biobank.Preventive medicine reports · 2026Article
- Screening, Diagnosis, Evaluation, and Staging of Obesity in Adults: Standards of Care in Overweight and Obesity-2026.BMJ open diabetes research & care · 2026Review
- Global, regional, and national burden of gallbladder and biliary tract cancer from 1990 to 2021 and projections to 2050: a systematic analysis integrating the Global Burden of Disease 2021 and Mendelian randomization.International journal of surgery (London, England) · 2026Article
- Genetic risk, antiseizure medications, and lifestyle factors in epilepsy-associated obesity and overweight.International journal of obesity (2005) · 2026Article
- A trans-omics gene-smoking interaction study of lung cancer based on consortium data.American journal of respiratory and critical care medicine · 2026Article
- Identification of novel candidate neural genes for diet-induced obesity in outbred heterogeneous stock rats.Research square · 2026Article
- Association of testosterone and sex hormone-binding globulin with chronic liver disease outcomes across sex and menopausal status.Biology of sex differences · 2026Article
- The metabolomic signatures mediate associations between physical frailty and metabolic dysfunction-associated steatotic liver disease.Science advances · 2026Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Min Seo KimDepartment of Digital Health, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul 06355, Republic of Korea; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.
Injeong ShimDepartment of Digital Health, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul 06355, Republic of Korea; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.
Akl C FahedCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Ron DoThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Woong-Yang ParkSamsung Genome Institute, Samsung Medical Center, Seoul 06351, Republic of Korea.
Pradeep NatarajanCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Amit V KheraDepartment of Medicine, Harvard Medical School, Boston, MA 02115, USA; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Verve Therapeutics, Boston, MA 02215, USA. Electronic address: avkhera@partners.org.
Hong-Hee WonDepartment of Digital Health, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul 06355, Republic of Korea; Samsung Genome Institute, Samsung Medical Center, Seoul 06351, Republic of Korea. Electronic address: wonhh@skku.edu.
Funding
Polygenic Risk Scores for Diverse Populations - Bridging Research and Clinical CareR01HL151152 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Christy Leigh Avery, Jennifer Below · 2020 to 2026
$12.3MUsing genetic variation to study biology of blood lipids & coronary heart diseaseR01HL127564 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Pradeep Natarajan, Gina Marie Peloso · 2015 to 2026
$7.3MClonal hematopoiesis in the Womens Health Initiative Memory StudyR01HL148565 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ALEXANDER P REINER, Eric A. Whitsel · 2019 to 2026
$5.9MClonal hematopoiesis in humans: determinants of development and progressionR01HL148050 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI BALLANTYNE, CHRISTIE MITCHELL, NATARAJAN, PRADEEP · 2019 to 2022
$5.9MEnabling improved applicability and transferability of polygenic scores across populationsU01HG011719 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI Alicia Martin · 2021 to 2026
$5.5MWhole genome sequences in individuals to comprehensively characterize the genetic mechanisms of dyslipidemiasR01HL142711 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Satoshi Koyama, Gina Marie Peloso · 2019 to 2026
$4.7MTowards an integrated map of causal connections for common, complex diseasesR35GM124836 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ron Do · 2017 to 2026
$3.9MElucidating hereditary transthyretin-mediated heart failure risk using machine learning, polygenic risk and recall by genotype approaches in African ancestry individualsR01HL155915 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DO, RON, NADKARNI, GIRISH NITIN · 2021 to 2024
$3.4MCoronary plaque changes with statin and colchicine among people with high polygenic risk- a mechanistic pilot studyR01HL164629 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Akl C Fahed, Michael TseYin Lu · 2023 to 2026
$3.3MCLONAL HEMATOPOIESIS OF INDETERMINATE POTENTIAL IN CHRONIC KIDNEY DISEASE PATIENTSR01DK125782 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KELLY, TANIKA NICOLE · 2021 to 2025
$3.3MStress-rest calf muscle perfusion: a functional diagnostic test for peripheral arterial disease (PAD)R01HL135242 · NHLBI · UNIVERSITY OF UTAH · PI NATARAJAN, PRADEEP · 2017 to 2020
$2.8MClonal hematopoiesis of indeterminate potential and HIV in the REPRIEVE trialR01HL151283 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NATARAJAN, PRADEEP · 2020 to 2023
$2.5MNHGRI NIH HHS U01 HG011719NHLBI NIH HHS K08 HL161448NHLBI NIH HHS R01 HL127564NHLBI NIH HHS R01 HL135242NHLBI NIH HHS R01 HL139865NHLBI NIH HHS R01 HL142711NHLBI NIH HHS R01 HL148050NHLBI NIH HHS R01 HL148565NHLBI NIH HHS R01 HL151152NHLBI NIH HHS R01 HL151283NHLBI NIH HHS R01 HL155915NHLBI NIH HHS R01 HL164629NIDDK NIH HHS R01 DK125782NIGMS NIH HHS R35 GM124836
Abstract
The extent to which modifiable lifestyle factors offset the determined genetic risk of obesity and obesity-related morbidities remains unknown. We explored how the interaction between genetic and lifestyle factors influences the risk of obesity and obesity-related morbidities. The polygenic score for body mass index was calculated to quantify inherited susceptibility to obesity in 338,645 UK Biobank European participants, and a composite lifestyle score was derived from five obesogenic factors (physical activity, diet, sedentary behavior, alcohol consumption, and sleep duration). We observed significant interaction between high genetic risk and poor lifestyles (p
Indexed as
Body Mass IndexGenetic Predisposition to DiseaseLife StyleObesityAdultAgedExerciseFemaleHumansMaleMiddle AgedRisk FactorsSedentary BehaviorUnited Kingdombody mass indexgene-environment interactiongenetic risklifestyleobesityobesity-related morbiditiespolygenic score
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.