Evidence map›Paper›PMID 38959455›Full record

ArticleJournal of medicinal chemistry2024

More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5-

Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener and 8 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Cellular Context Influences Kinase Inhibitor Selectivity.Journal of medicinal chemistry · 2026
    Article
  3. Article
  4. Access to Pyrazolo[1,5-Organic letters · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Development of a Second-Generation,Journal of medicinal chemistry · 2025
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Han Wee OngRapidly Emerging Antiviral Drug Development Initiative (READDI), Chapel Hill, North Carolina 27599, United States.ORCID 0000-0003-3232-2373
Xuan YangRapidly Emerging Antiviral Drug Development Initiative (READDI), Chapel Hill, North Carolina 27599, United States.
Jeffery L SmithStructural Genomics Consortium (SGC) and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Rebekah J DickmanderRapidly Emerging Antiviral Drug Development Initiative (READDI), Chapel Hill, North Carolina 27599, United States.
Jason W BrownTakeda Development Center Americas, Inc., San Diego, California 92121, United States.
Tammy M HavenerStructural Genomics Consortium (SGC) and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.ORCID 0000-0002-4613-0498
Sharon Taft-BenzRapidly Emerging Antiviral Drug Development Initiative (READDI), Chapel Hill, North Carolina 27599, United States.
Stefanie HowellStructural Genomics Consortium (SGC) and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Marcia K SandersRapidly Emerging Antiviral Drug Development Initiative (READDI), Chapel Hill, North Carolina 27599, United States.
Jacob L CapenerStructural Genomics Consortium (SGC) and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Rafael M CouñagoStructural Genomics Consortium (SGC) and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.ORCID 0000-0003-1847-5090
Edcon ChangTakeda Development Center Americas, Inc., San Diego, California 92121, United States.ORCID 0000-0001-9534-0291
Andreas KrämerSGC, Institute of Pharmaceutical Chemistry, Goethe University Frankfurt am Main, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany.
Nathaniel J MoormanRapidly Emerging Antiviral Drug Development Initiative (READDI), Chapel Hill, North Carolina 27599, United States.
Mark HeiseRapidly Emerging Antiviral Drug Development Initiative (READDI), Chapel Hill, North Carolina 27599, United States.
Alison D AxtmanRapidly Emerging Antiviral Drug Development Initiative (READDI), Chapel Hill, North Carolina 27599, United States.ORCID 0000-0003-4779-9932
David H DrewryRapidly Emerging Antiviral Drug Development Initiative (READDI), Chapel Hill, North Carolina 27599, United States.ORCID 0000-0001-5973-5798
Timothy M WillsonRapidly Emerging Antiviral Drug Development Initiative (READDI), Chapel Hill, North Carolina 27599, United States.ORCID 0000-0003-4181-8223

Funding

Illuminating Function of the Understudied Druggable KinomeU24DK116204 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JOHNSON, GARY L. · 2017 to 2022
$13.6M
Request for a 500 MHz NMR console and nitrogen-cooled cryoprobeS10OD032476 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEE, ANDREW L · 2022 to 2022
$599k
NIDDK NIH HHS U24 DK116204NIH HHS S10 OD032476
6 · The paper itself

Abstract

The pyrazolo[1,5-

Indexed as

Antiviral AgentsCasein Kinase IIPyrimidinesTriazolesVirus ReplicationAmidesAnimalsDrug DiscoveryHumansMaleMiceProtein Kinase InhibitorsPyrazolesRatsSARS-CoV-2Structure-Activity Relationship1,2,4-triazoleAmidesAntiviral AgentsCasein Kinase IIProtein Kinase InhibitorsPyrazolespyrazolo(1,5-a)pyrimidinePyrimidinesTriazoles

Identifiers

PMID38959455
PMCPMC11284802

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.