SynthesisPediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2024
Executive Summary: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE (PEACE) Consensus Conference.
Abstract readConsensus StatementSystematic Review
In one paragraph
Synthesis in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 9 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 9 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Priorities for Clinical Research in Pediatric Extracorporeal Membrane Oxygenation Anticoagulation From the Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2024Pooled it
- Recommendations on Monitoring and Replacement of Antithrombin, Fibrinogen, and Von Willebrand Factor in Pediatric Patients on Extracorporeal Membrane Oxygenation: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2024Pooled it
- Management of Extracorporeal Membrane Oxygenation Anticoagulation in the Perioperative Period: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2024Pooled it
- Prophylactic Transfusion Strategies in Children Supported by Extracorporeal Membrane Oxygenation: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2024Pooled it
- Antifibrinolytic and Adjunct Hemostatic Agents: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2024Pooled it
- Anticoagulation Monitoring and Targets: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2024Pooled it
- The Influence of the Extracorporeal Membrane Oxygenation Circuit and Components on Anticoagulation Management: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2024Pooled it
- Management of Bleeding and Thrombotic Complications During Pediatric Extracorporeal Membrane Oxygenation: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2024Pooled it
- Anticoagulant Medications: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2024Pooled it
- Platelet Transfusion Thresholds for Children Supported by Extracorporeal Membrane Oxygenation: The Extracorporeal Membrane Oxygenation Hemostatic Transfusions in Children (ECSTATIC) Feasibility Clinical Trial.Critical care medicine · 2026Trial
- Prospective Randomized Pilot Study Comparing Bivalirudin Versus Heparin in Neonatal and Pediatric Extracorporeal Membrane Oxygenation.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025Trial
- Consensus statement of the Paediatric Anaesthesiology and Intensive Therapy Section of the Polish Society of Anaesthesiology and Intensive Therapy on the use of VV ECMO in paediatric patients for the treatment of acute respiratory failure.Anaesthesiology intensive therapy · 2026Article
- Performance of Thromboelastography 6s Difference in Reaction Time Between Heparinase-Free and Heparinase-Containing Channel for Detecting Subtherapeutic Unfractionated Heparin Anticoagulation in a Pediatric Cardiac ICU.Critical care explorations · 2026Observational
- Anticoagulation management and monitoring in ECMO: an international survey: communication from the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis.Research and practice in thrombosis and haemostasis · 2026Article
- ECMO-induced coagulopathy: strategic initiatives for research and clinical practice (a workshop report of the NHLBI).Blood vessels, thrombosis & hemostasis · 2025Review
- Hemostatic Outcome Definitions in Pediatric Extracorporeal Membrane Oxygenation: Challenges in Cohorts From Rotterdam (2019-2023) and Melbourne (2016-2022).Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025Article
- New perspectives on extracorporeal life support: expert teams and precise selection of candidates are transforming pediatric cancer and hematopoietic cell transplantation care.Frontiers in oncology · 2025Article
- Successful VA ECMO on an adolescent pre-B cell acute lymphoblastic leukemia patient with necrotizing fasciitis fromArchive of clinical cases · 2025Article
- Bivalirudin as an Alternative to Heparin in Pediatric Cardiac Procedures: Evidence, Challenges, and Future Directions.Sage open pediatricsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
54 authors.
Peta M A AlexanderDepartment of Cardiology, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA.
Melania M BembeaDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Katherine CashenDepartment of Pediatrics, Duke Children's Hospital, Duke University, Durham, NC.
Ira M CheifetzDepartment of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, OH.
Heidi J DaltonDepartment of Pediatrics, INOVA Fairfax Medical Center, Falls Church, VA.
Adam S HimebauchDepartment of Anesthesiology and Critical Care Medicine, Division of Critical Care Medicine, The Children's Hospital of Philadelphia, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA.
Oliver KaramDivision of Critical Care Medicine, Children's Hospital of Richmond at VCU, Richmond, VA.
Katie M MoynihanDepartment of Cardiology, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA.
Marianne E NellisDepartment of Pediatrics, Division of Pediatric Critical Care Medicine, New York Presbyterian Hospital-Weill Cornell, New York, NY.
Caroline OzmentDivision of Critical Care Medicine, Department of Pediatrics, Duke University and Duke University Health System, Durham, NC.
Lakshmi RamanDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
Natalie E RintoulDepartment of Pediatrics, Division of Neonatology, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Ahmed S SaidDivision of Pediatric Critical Care, Department of Pediatrics, Washington University in St. Louis, St. Louis, MO.
Arun SainiDepartment of Pediatrics, Section of Pediatric Critical Care Medicine, Texas Children's Hospital, Baylor College of Medicine, Houston, TX.
Marie E SteinerDepartment of Pediatrics, Divisions of Hematology and Critical Care, University of Minnesota, Minneapolis, MN.
Ravi R ThiagarajanDepartment of Cardiology, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA.
Kevin WattDivision of Clinical Pharmacology, Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT.
Ariane WillemsPediatric Intensive Care Unit, Department of Intensive Care, Leiden University Medical Centre, Leiden, The Netherlands.
Nicole D ZantekDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Ryan P BarbaroDivision of Pediatric Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, MI.
Katherine SteffenDepartment of Pediatrics (Pediatric Critical Care Medicine), Stanford University, Palo Alto, CA.
Adam M VogelDepartments of Surgery and Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, TX.
Christopher AlmondDepartment of Pediatrics (Cardiology), Stanford University School of Medicine, Palo Alto, CA.
Marc M AndersDepartment of Pediatrics, Section of Pediatric Critical Care Medicine, Texas Children's Hospital, Baylor College of Medicine, Houston, TX.
Gail M AnnichDepartment of Critical Care Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
Leonardo R BrandãoDepartment of Pediatrics, The Hospital for Sick Children, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Wayne ChandlerDepartment of Laboratories, Seattle Children's Hospital, Seattle, WA.
Megan DelaneyDivision of Pathology and Lab Medicine and Transfusion Medicine, Children's National Hospital, Washington, DC.
Robert DiGeronimoDepartment of Pediatrics, Division of Neonatology, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, WA.
Sitaram EmaniDepartment of Cardiovascular Surgery, Boston Children's Hospital, and Department of Surgery, Harvard Medical School, Boston, MA.
Samir K GadepalliDivision of Pediatric Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI.
Alejandro V GarciaDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Bereketeab HaileselassieDepartment of Pediatrics (Pediatric Critical Care Medicine), Stanford University, Palo Alto, CA.
Robert HyslopHeart Institute, Children's Hospital of Colorado, Aurora, CO.
Martin C J KneyberDepartment of Paediatrics, Division of Paediatric Critical Care Medicine, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Lisa Baumann KreuzigerVersiti Blood Research Institute and Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI.
Jennifer LeSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA.
Laura LoftisDepartment of Pediatrics, Section of Pediatric Critical Care Medicine, Texas Children's Hospital, Baylor College of Medicine, Houston, TX.
Ali B V McMichaelDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
D Michael McMullanDivision of Pediatric Cardiac Surgery, Seattle Children's Hospital, Seattle, WA.
Paul MonagleUniversity of Melbourne, and Kids Cancer Centre Sydney Children's Hospital, and Murdoch Children's Research Institute, and Royal Children's Hospital Melbourne Australia, Melbourne, VIC, Australia.
Kathleen NicolDepartment of Pathology, Nationwide Children's Hospital, Columbus, OH.
Matthew L PadenChildren's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA.
Jason PatregnaniDepartment of Pediatrics, Division of Pediatric Critical Care Medicine, Barbara Bush Children's Hospital, Portland, ME.
John PriestDepartment of Respiratory Care, Boston Children's Hospital, Boston MA.
Leslie RaffiniDepartment of Pediatrics, Division of Hematology, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA.
Lindsay M RyersonDepartment of Pediatrics, Stollery Children's Hospital, University of Alberta, Edmonton, AB, Canada.
Steven R SloanDepartment of Laboratory Medicine, Boston Children's Hospital, Boston, MA.
Jun TeruyaDivision of Transfusion Medicine and Coagulation, Texas Children's Hospital and Baylor College of Medicine, Houston, TX.
Andrew R YatesDepartment of Pediatrics, Divisions of Cardiology and Critical Care Medicine, Nationwide Children's Hospital and the Ohio State University College of Medicine, Columbus, OH.
Alison GehredGrant Morrow III MD Medical Library, Nationwide Children's Hospital Columbus, Columbus, OH.
Elizabeth LymanGrant Morrow III MD Medical Library, Nationwide Children's Hospital Columbus, Columbus, OH.
Jennifer A MuszynskiDepartment of Pediatrics, Division of Critical Care Medicine, Nationwide Children's Hospital and The Ohio State University of Medicine, Columbus, OH.
Pediatric ECMO Anticoagulation CollaborativE (PEACE), in collaboration with the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric ECMO subgroup of PALISI and the Extracorporeal Life Support Organization (PediECMO)
Funding
ASCEND (ARDS in Children and ECMO initiation strategies impact on Neuro-Development)R01HL153519 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARBARO, RYAN PASQUALE · 2020 to 2024
$3.4MTraining to Advance Care Through Implementation Science in Cardiac And Lung Illnesses (TACTICAL)K12HL138039 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARNES, GEOFFREY DOUGLAS, PRESCOTT, HALLIE CHRISTINE · 2017 to 2021
$3.1MThe Roles of Pulmonary Hypertension and Right Ventricular Dysfunction in Pediatric Acute Respiratory Distress SyndromeK23HL153759 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI HIMEBAUCH, ADAM S. · 2021 to 2025
$879kECmo hemoSTAtic Transfusions In Children (ECSTATIC)R34HL159119 · NHLBI · YALE UNIVERSITY · PI KARAM, OLIVER L, NELLIS, MARIANNE · 2022 to 2024
$830kPediatric ECMO Anticoagulation Collaborative (PEACE) ConsensusR13HD104432 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI ALEXANDER, PETA-MAREE ANN, MUSZYNSKI, JENNIFER · 2021 to 2021
$75kNHLBI NIH HHS K12 HL138039NHLBI NIH HHS K23 HL153759NHLBI NIH HHS R01 HL153519NHLBI NIH HHS R34 HL159119NICHD NIH HHS R13 HD104432
Abstract
objectivesTo present recommendations and consensus statements with supporting literature for the clinical management of neonates and children supported with extracorporeal membrane oxygenation (ECMO) from the Pediatric ECMO Anticoagulation CollaborativE (PEACE) consensus conference. DATA SOURCES: Systematic review was performed using PubMed, Embase, and Cochrane Library (CENTRAL) databases from January 1988 to May 2021, followed by serial meetings of international, interprofessional experts in the management ECMO for critically ill children. STUDY SELECTION: The management of ECMO anticoagulation for critically ill children. DATA EXTRACTION: Within each of eight subgroup, two authors reviewed all citations independently, with a third independent reviewer resolving any conflicts. DATA SYNTHESIS: A systematic review was conducted using MEDLINE, Embase, and Cochrane Library databases, from January 1988 to May 2021. Each panel developed evidence-based and, when evidence was insufficient, expert-based statements for the clinical management of anticoagulation for children supported with ECMO. These statements were reviewed and ratified by 48 PEACE experts. Consensus was obtained using the Research and Development/UCLA Appropriateness Method. Results were summarized using the Grading of Recommendations Assessment, Development, and Evaluation method. We developed 23 recommendations, 52 expert consensus statements, and 16 good practice statements covering the management of ECMO anticoagulation in three broad categories: general care and monitoring; perioperative care; and nonprocedural bleeding or thrombosis. Gaps in knowledge and research priorities were identified, along with three research focused good practice statements.
conclusionsThe 91 statements focused on clinical care will form the basis for standardization and future clinical trials.
Indexed as
AnticoagulantsCritical IllnessExtracorporeal Membrane OxygenationChildChild, PreschoolHumansInfantInfant, NewbornAnticoagulants
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