ArticleScience translational medicine2024
PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections.
Abstract read
In one paragraph
Article in Science translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Immune-endothelial-coagulation crosstalk as a driver of multi-organ dysfunction in severe viral pneumonia.Frontiers in immunology · 2026Review
- Mechanisms That Prevent Vascular Leakage During Leukocyte Extravasation.Acta physiologica (Oxford, England) · 2025Review
- PI3Kγ in Tumour Inflammation: Bridging Immune Response and Cancer Progression-A Mini-Review.Immunology · 2025Review
- One Step Ahead: Preventing Tumor Adaptation to Immune Therapy.American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting · 2025Review
- Characteristics of SARS-CoV-2-associated severe episodes of monoclonal gammopathy-associated capillary leak syndrome (Clarkson disease).Annals of intensive care · 2025Article
- Targeting PI3Kγ in cancer.Trends in cancer · 2025Review
- Recent advances in TAM mechanisms in lung diseases.Journal of translational medicine · 2025Review
- The Role of PI3k-Gamma Modulation in Bacterial Infection: A Review of the Literature and Selected Experimental Observations.Antibiotics (Basel, Switzerland) · 2025Review
- Targeting myeloid cells to improve cancer immune therapy.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
42 authors.
Ryan M ShepardMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-7488-369X
Anghesom GhebremedhinMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-7132-6820
Isaraphorn PratumchaiDepartment of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-3781-242X
Sally R RobinsonDepartment of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.ORCID 0000-0003-4711-1667
Courtney BettsDepartment of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR 97201, USA.
Jingjing HuDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
Roman SasikCenter for Computational Biology and Bioinformatics, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-9266-8993
Kathleen M FischCenter for Computational Biology and Bioinformatics, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-0117-7444
Jaroslav ZakDepartment of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-8135-856X
Hui ChenMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
Marc ParadiseMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
Jason RiveraMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
Mohammad AmjadMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
Satoshi UchiyamaDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
Hideya SeoDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-8823-8608
Alejandro D CamposDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-1645-4862
Denise Ann DayaoDepartment of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.ORCID 0000-0001-9570-7807
Saul TziporiDepartment of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.
Cesar Piedra-MoraDepartment of Comparative Pathobiology, Section of Pathology, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA.ORCID 0000-0003-1146-7717
Soumita DasDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-3895-3643
Farnaz HastehDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
Hana RussoDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0009-0001-9799-5985
Xin SunDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-8387-4966
Le XuDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-6321-5023
Laura E Crotty AlexanderDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-5091-2660
Jason M DuranDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-1666-2319
Mazen OdishDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-1247-1371
Victor PretoriusDepartment of Surgery, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-6360-4002
Nell C KirchbergerDepartment of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR 97201, USA.ORCID 0009-0003-7024-705X
Shao-Ming ChinMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-6526-6083
Tami Von SchalschaDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0009-0007-8348-6200
David ChereshDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-7193-8595
John D MorreyInstitute for Antiviral Research, Animal, Dairy, and Veterinary Science, Utah State University, Logan, UT 84322, USA.
Rossitza AlargovaInfinity Pharmaceuticals, Cambridge, MA 02138, USA.
Brenda O'ConnellInfinity Pharmaceuticals, Cambridge, MA 02138, USA.
Theodore A MartinotInfinity Pharmaceuticals, Cambridge, MA 02138, USA.ORCID 0000-0003-2290-9621
Sandip P PatelDepartment of Medicine/Medical Oncology, University of California, San Diego, La Jolla, CA 92093, USA.
Victor NizetDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-3847-0422
Amanda J MartinotDepartment of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.ORCID 0000-0001-6237-6191
Lisa M CoussensDepartment of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR 97201, USA.ORCID 0000-0003-2389-1865
John R TeijaroDepartment of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0001-8280-8887
Judith A VarnerMoores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-9251-0600
Funding
VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9MUC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3MResources and workforce development for the New England Regional Biosafety LaboratoryUC7AI180310 · NIAID · TUFTS UNIVERSITY BOSTON · PI Sam R Telford · 2023 to 2026
$11.8MUCSD Cancer Center Training Program in Drug DevelopmentT32CA121938 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Michael Bouvet, Dwayne G. Stupack · 2006 to 2026
$10.3MRole of PI3Kinase in Tumor Progression and MetastasisR01CA167426 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Judith A VARNER · 2012 to 2026
$5.8MTargeting the innate immune response in HNSCCR01DE027325 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Judith A VARNER · 2017 to 2026
$4.8MBiomimetic Macrophage Membrane-Coated Nanosponges: A Novel Therapeutic for Multidrug-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii Hospital-Associated PneumoniaR01AI176554 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Angela Meier, Victor Nizet · 2023 to 2026
$4.0MTherapeutic Targeting of Macrophage PI3Kgamma in HNSCCR01CA226909 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Kathryn Ann Gold, Judith A VARNER · 2018 to 2026
$3.9MIllumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600kDigital pathology for defining myeloid cell-mediated lung injury during acute SARS CoV-2 Infection in hamstersR21AI166743 · NIAID · TUFTS UNIVERSITY BOSTON · PI MARTINOT, AMANDA, TZIPORI, SAUL R · 2022 to 2023
$454kNCATS NIH HHS UL1 TR001442NCI NIH HHS P30 CA023100NCI NIH HHS R01 CA167426NCI NIH HHS R01 CA226909NCI NIH HHS T32 CA121938NIAID NIH HHS HHSN272201700041INIAID NIH HHS R01 AI176554NIAID NIH HHS R21 AI166743NIAID NIH HHS UC7 AI180310NIDCR NIH HHS R01 DE027325NIH HHS S10 OD026929
Abstract
Virulent infectious agents such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and methicillin-resistant
Indexed as
Class Ib Phosphatidylinositol 3-KinaseCOVID-19InflammationSARS-CoV-2AnimalsCapillary PermeabilityCOVID-19 Drug TreatmentCytokine Release SyndromeHumansLungMethicillin-Resistant Staphylococcus aureusMiceMice, Inbred C57BLPhosphoinositide-3 Kinase InhibitorsStaphylococcal InfectionsClass Ib Phosphatidylinositol 3-KinasePhosphoinositide-3 Kinase InhibitorsPik3cg protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.