ArticleScience advances2024
Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response.
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Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Understanding and targeting the tumour matrisome.Nature reviews. Clinical oncology · 2026Review
- Screening and epitope characterization of Nidogen-2-specific nanobodies.FEBS open bio · 2026Article
- Evaluation of NID2 and CDO1 methylation for ovarian cancer screening.Oncology letters · 2026Article
- Glutamine-dependent changes in fibroblast-derived extracellular matrix dictate cancer cell behavior.Matrix biology : journal of the International Society for Matrix Biology · 2026Article
- GREM1 acts in leptin receptor-expressing skeletal cells to mediate peri-implant fibrosis.Nature communications · 2026Article
- SUSD2 Promotes Metastasis and Primary Tumor Growth in Pancreatic Cancer Cells via Integrin-FAK Signaling Activation.Cancer science · 2026Article
- Mechanistic insights into hepatic metastasis of pancreatic cancer: molecular perspectives.Translational gastroenterology and hepatology · 2026Review
- The tumour microenvironment in pancreatic cancer - new clinical challenges, but more opportunities.Nature reviews. Clinical oncology · 2025Review
- Tumor microenvironment phenotyping guides precision therapy in unresectable pancreatic cancer.World journal of gastrointestinal oncology · 2025Review
- Transcriptomic Features of Recurrence Rates in Idiopathic Subglottic Stenosis.The Laryngoscope · 2025Article
- Targeting the NPY/NPY1R signaling axis in mutant p53-dependent pancreatic cancer impairs metastasis.Science advances · 2025Article
- The role of inflammatory factors in the tumor microenvironment of pancreatic cancer.Frontiers in immunology · 2025Review
- Nidogen 2 Overexpression Promotes Hepatosteatosis and Atherosclerosis.International journal of molecular sciences · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
66 authors.
Brooke A PereiraCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0003-3513-1214
Shona RitchieCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0001-9234-0632
Cecilia R ChambersCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0002-4979-9349
Katie A GordonCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.
Astrid MagenauCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.
Kendelle J MurphyCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0002-3234-3812
Max NobisCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0002-1861-1390
Victoria M TymaCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0009-0005-7959-4407
Ying Fei LiewCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.
Morghan C LucasCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0001-7654-9137
Marjan M NaeiniSchool of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.ORCID 0000-0003-1422-1106
Deborah S BarkauskasCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0002-1872-4109
Diego Chacon-FajardoSchool of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.ORCID 0000-0003-3729-1385
Anna E HowellCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0002-6207-182X
Amelia L ParkerCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.
Sean C WarrenCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0002-5253-7147
Daniel A ReedCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0002-3736-7725
Victoria LeeCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0002-0701-8321
Xanthe L MetcalfCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0001-9599-9280
Young Kyung LeeCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0003-0212-0164
Luke P O'ReganCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0009-0003-2398-5818
Jessie ZhuCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.
Michael TrpceskiCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0001-5430-2205
Angela R M FontaineCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0002-5032-8026
Janett StoehrCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0002-4198-3520
Romain RouetSchool of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.
Xufeng LinData Science Platform, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.ORCID 0000-0002-3400-8700
Jessica L ChittyCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0003-1776-1618
Sean PorazinskiSchool of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.
Sunny Z WuCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0002-6153-0449
Elysse C FilipeCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.
Antonia L CadellSchool of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.ORCID 0000-0002-3560-4125
Holly HollidayCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0002-3022-0114
Jessica YangCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0003-1513-7942
Michael PapanicolaouCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0002-7998-3171
Ruth J LyonsCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.
Anaiis ZaratzianHistopathology Platform, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.
Michael TayaoHistopathology Platform, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0001-5224-0784
Andrew Da SilvaHistopathology Platform, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.
Claire VenninCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0009-0001-3940-5780
Julia YinSchool of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.ORCID 0000-0002-7706-5895
Alysha B DewCentre for Advanced Histology & Microscopy, Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.
Paul J McMillanCentre for Advanced Histology & Microscopy, Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.ORCID 0000-0001-5629-1175
Leonard D GoldsteinSchool of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.ORCID 0000-0003-4645-553X
Ira W DevesonSchool of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.ORCID 0000-0003-3861-0472
David R CroucherSchool of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.ORCID 0000-0003-4965-8674
Michael S SamuelCentre for Cancer Biology, An Alliance of SA Pathology and University of South Australia, Adelaide, South Australia, Australia.ORCID 0000-0001-7880-6379
Hao-Wen SimCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0002-2530-0523
Marcel BattenCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0002-3726-3790
Lorraine ChantrillCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0002-5790-0208
Sean M GrimmondCentre for Cancer Research and Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia.ORCID 0000-0002-8102-7998
Anthony J GillCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0002-9447-1967
Jaswinder SamraDepartment of Surgery, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Thomas R Jeffry EvansCancer Research UK Beatson Institute, Glasgow, UK.ORCID 0000-0001-5201-885X
Takako SasakiDepartment of Biochemistry, Faculty of Medicine, Oita University, Oita, Japan.ORCID 0000-0003-0514-9931
Tri G PhanSchool of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.ORCID 0000-0002-4909-2984
Alexander SwarbrickCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.
Owen J SansomCancer Research UK Beatson Institute, Glasgow, UK.ORCID 0000-0001-9540-3010
Jennifer P MortonCancer Research UK Beatson Institute, Glasgow, UK.ORCID 0000-0001-5766-9141
Australian Pancreatic Cancer Matrix Atlas (APMA)
Australian Pancreatic Cancer Genome Initiative (APGI)
Marina PajicSchool of Clinical Medicine, Faculty of Medicine, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.ORCID 0000-0002-3871-3829
Benjamin L ParkerDepartment of Anatomy and Physiology, University of Melbourne, Parkville, Victoria, Australia.ORCID 0000-0003-1818-2183
David HerrmannCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0002-9514-7501
Thomas R CoxCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0001-9294-1745
Paul TimpsonCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.ORCID 0000-0002-5514-7080
Funding
Cancer Research UK 29996
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is characterized by increasing fibrosis, which can enhance tumor progression and spread. Here, we undertook an unbiased temporal assessment of the matrisome of the highly metastatic KPC (
Indexed as
Carcinoma, Pancreatic DuctalPancreatic NeoplasmsProteomicsAnimalsCalcium-Binding ProteinsCancer-Associated FibroblastsCell Adhesion MoleculesCell Line, TumorDeoxycytidineDisease Models, AnimalFibrosisGemcitabineHumansMiceCalcium-Binding ProteinsCell Adhesion MoleculesDeoxycytidineGemcitabineNID2 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.