Evidence map›Paper›PMID 38958871›Full record

ArticleJournal of microbiology (Seoul, Korea)2024

Fleagrass (Adenosma buchneroides Bonati) Acts as a Fungicide Against Candida albicans by Damaging Its Cell Wall.

Youwei Wu, Hongxia Zhang, Hongjie Chen, Zhizhi Du, Qin Li, Ruirui Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of microbiology (Seoul, Korea), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Youwei Wu *College of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650000, People's Republic of China.
Hongxia Zhang *Department of Economic Plants and Biotechnology, Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
Hongjie ChenCollege of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650000, People's Republic of China.
Zhizhi DuDepartment of Economic Plants and Biotechnology, Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
Qin LiCollege of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650000, People's Republic of China.
Ruirui WangCollege of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650000, People's Republic of China. wangrryucm@126.com.ORCID http://orcid.org/0000-0001-5084-0647

Funding

Kunming Institute of Botany, Chinese Academy of Sciences E03K481261National Natural Science Foundation of China 82260805Yunnan Provincial Science and Technology Department 202101AF070001Yunnan Provincial Science and Technology Department 202103AC100005
6 · The paper itself

Abstract

Fleagrass, a herb known for its pleasant aroma, is widely used as a mosquito repellent, antibacterial agent, and for treating colds, reducing swelling, and alleviating pain. The antifungal effects of the essential oils of fleagrass and carvacrol against Candida albicans were investigated by evaluating the growth and the mycelial and biofilm development of C. albicans. Transmission electron microscopy was used to evaluate the integrity of the cell membrane and cell wall of C. albicans. Fleagrass exhibited high fungicidal activity against C. albicans at concentrations of 0.5% v/v (via the Ras1/cAMP/PKA pathway). Furthermore, transmission electron microscopy revealed damage to the cell wall and membrane after treatment with the essential oil, which was further confirmed by the increased levels of β-1,3-glucan and chitin in the cell wall. This study showed that fleagrass exerts good fungicidal and hyphal growth inhibition activity against C. albicans by disrupting its cell wall, and thus, fleagrass may be a potential antifungal drug.

Indexed as

Antifungal AgentsBiofilmsCandida albicansCell WallMicrobial Sensitivity TestsOils, Volatilebeta-GlucansChitinCymenesFabaceaeHyphaeMicroscopy, Electron, TransmissionMonoterpenesAntifungal Agentsbeta-1,3-glucanbeta-GlucanscarvacrolChitinCymenesMonoterpenesOils, VolatileAntifungal drugCandida albicansCarvacrolFleagrass

Identifiers

PMID38958871

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.