Evidence map›Paper›PMID 38958868›Full record

ReviewCurrent obesity reports2024

The Role of Physical Exercise as a Therapeutic Tool to Improve Lipedema: A Consensus Statement from the Italian Society of Motor and Sports Sciences (Società Italiana di Scienze Motorie e Sportive, SISMeS) and the Italian Society of Phlebology (Società Italiana di Flebologia, SIF).

Giuseppe Annunziata, Antonio Paoli, Vincenzo Manzi, Elisabetta Camajani, Francesco Laterza, Ludovica Verde, Xavier Capó, Elvira Padua, Antonino Bianco, Attilio Carraro and 15 more

Abstract readReviewConsensus Statement
In one paragraph

Review in Current obesity reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Lipedema: Progress, Challenges, and the Road Ahead.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Pooled it
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  10. Vascular changes and their implications in lipedema.Frontiers in cell and developmental biology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Giuseppe Annunziata *Facoltà di Scienze Umane, Della Formazione e dello Sport, Università Telematica Pegaso, Via Porzio, Centro Direzionale, Isola F2, 80143, Naples, Italy.ORCID http://orcid.org/0000-0002-1922-662X
Antonio Paoli *Department of Biomedical Sciences, University of Padua, Padua, Italy.ORCID http://orcid.org/0000-0003-0474-4229
Vincenzo Manzi *Department of Wellbeing, Nutrition and Sport, Pegaso Telematic University, Centro Direzionale Isola F2, Via Porzio, 80143, Naples, Italy.ORCID http://orcid.org/0000-0002-0331-5417
Elisabetta CamajaniDepartment of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, Italy.ORCID http://orcid.org/0000-0002-1866-8223
Francesco LaterzaDepartment of Wellbeing, Nutrition and Sport, Pegaso Telematic University, Centro Direzionale Isola F2, Via Porzio, 80143, Naples, Italy.ORCID http://orcid.org/0009-0009-4038-273X
Ludovica VerdeDepartment of Public Health, University of Naples Federico II, Via Sergio Pansini 5, 80131, Naples, Italy.ORCID http://orcid.org/0000-0002-4583-8283
Xavier CapóTranslational Research In Aging and Longevity (TRIAL) Group, Health Research Institute of the Balearic Islands (IdISBa), 07120, Palma, Spain.ORCID http://orcid.org/0000-0002-3499-5494
Elvira PaduaDepartment of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, Italy.ORCID http://orcid.org/0000-0001-5227-2567
Antonino BiancoItalian Society of Motor and Sports Sciences, (Società Italiana di Scienze Motorie e Sportive, SISMeS), Verona, Italy.ORCID http://orcid.org/0000-0001-8334-6581
Attilio CarraroItalian Society of Motor and Sports Sciences, (Società Italiana di Scienze Motorie e Sportive, SISMeS), Verona, Italy.ORCID http://orcid.org/0000-0002-5103-6236
Angela Di BaldassarreItalian Society of Motor and Sports Sciences, (Società Italiana di Scienze Motorie e Sportive, SISMeS), Verona, Italy.ORCID http://orcid.org/0000-0002-4473-4909
Laura GuidettiItalian Society of Motor and Sports Sciences, (Società Italiana di Scienze Motorie e Sportive, SISMeS), Verona, Italy.ORCID http://orcid.org/0000-0002-1419-4550
Samuele Maria MarcoraItalian Society of Motor and Sports Sciences, (Società Italiana di Scienze Motorie e Sportive, SISMeS), Verona, Italy.ORCID http://orcid.org/0000-0002-1570-7936
Stefania OrrùItalian Society of Motor and Sports Sciences, (Società Italiana di Scienze Motorie e Sportive, SISMeS), Verona, Italy.ORCID http://orcid.org/0000-0002-6697-9413
Antonio TessitoreItalian Society of Motor and Sports Sciences, (Società Italiana di Scienze Motorie e Sportive, SISMeS), Verona, Italy.ORCID http://orcid.org/0000-0002-3542-0991
Roberto Di MitriCenter for Diagnosis and Treatment of Vascular Diseases, San Rossore Clinic Pisa, Pisa, Italy.ORCID http://orcid.org/0009-0000-9385-3958
Lucia AulettaItalian Society of Phlebology (Società Italiana Di Flebologia, SIF), Caserta, Italy.ORCID http://orcid.org/0009-0004-1053-8776
Angela PiantadosiItalian Society of Phlebology (Società Italiana Di Flebologia, SIF), Caserta, Italy.ORCID http://orcid.org/0009-0000-9238-5507
Mario BellisiItalian Society of Phlebology (Società Italiana Di Flebologia, SIF), Caserta, Italy.ORCID http://orcid.org/0000-0002-5504-6810
Edmondo PalmeriItalian Society of Phlebology (Società Italiana Di Flebologia, SIF), Caserta, Italy.ORCID http://orcid.org/0009-0005-8162-6359
Silvia SavastanoUnità di Endocrinologia, Diabetologia e Andrologia, Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131, Naples, Italy.ORCID http://orcid.org/0000-0002-3211-4307
Annamaria ColaoUnità di Endocrinologia, Diabetologia e Andrologia, Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131, Naples, Italy.ORCID http://orcid.org/0000-0003-4049-2559
Massimiliano Caprio *Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, Italy.ORCID http://orcid.org/0000-0003-0722-7163
Giovanna Muscogiuri *Unità di Endocrinologia, Diabetologia e Andrologia, Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131, Naples, Italy. giovanna.muscogiuri@unina.it.ORCID http://orcid.org/0000-0002-8809-4931
Luigi Barrea *Department of Wellbeing, Nutrition and Sport, Pegaso Telematic University, Centro Direzionale Isola F2, Via Porzio, 80143, Naples, Italy.ORCID http://orcid.org/0000-0001-9054-456X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis consensus statement from the Italian Society of Motor and Sports Sciences (Società Italiana di Scienze Motorie e Sportive, SISMeS) and the Italian Society of Phlebology (Società Italiana di Flebologia, SIF) provides the official view on the role of exercise as a non-pharmacological approach in lipedema. In detail, this consensus statement SISMeS - SIF aims to provide a comprehensive overview of lipedema, focusing, in particular, on the role played by physical exercise (PE) in the management of its clinical features. RECENT

findingsLipedema is a chronic disease characterized by abnormal fat accumulation. It is often misdiagnosed as obesity, despite presenting distinct pathological mechanisms. Indeed, recent evidence has reported differences in adipose tissue histology, metabolomic profiles, and gene polymorphisms associated with this condition, adding new pieces to the complex puzzle of lipedema pathophysiology. Although by definition lipedema is a condition resistant to diet and PE, the latter emerges for its key role in the management of lipedema, contributing to multiple benefits, including improvements in mitochondrial function, lymphatic drainage, and reduction of inflammation. Various types of exercise, such as aquatic exercises and strength training, have been shown to alleviate symptoms and improve the quality of life of patients with lipedema. However, standardized guidelines for PE prescription and long-term management of patients with lipedema are lacking, highlighting the need for recommendations and further research in this area in order to optimise therapeutic strategies.

Indexed as

ConsensusExercise TherapyLipedemaAdipose TissueExerciseHumansItalyObesityBMIHormonesLipedemaObesityPhysical activitySport

Identifiers

PMID38958868
PMCPMC11522091

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