Evidence map›Paper›PMID 38958847›Full record

ArticleHead and neck pathology2024

Clinicopathological Features of 26 Intraoral Polymorphous Adenocarcinomas from a Single Brazilian Institution.

Sibele Nascimento de Aquino, Cinthia Veronica Bardález López de Cáceres, Hélen Kaline Farias Bezerra, João Paulo Gonçalves de Paiva, Brendo Vinícius Rodrigues Louredo, Alan Roger Santos-Silva, Márcio Ajudarte Lopes, Pablo Agustin Vargas

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In one paragraph

Article in Head and neck pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Salivary gland microsecretory adenocarcinoma: a case series study and literature review.Virchows Archiv : an international journal of pathology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sibele Nascimento de AquinoApplied Health Sciences Post-Graduate Program, Federal University of Juiz de Fora, Governador Valadares, Minas Gerais, Brazil.ORCID http://orcid.org/0000-0003-3843-3517
Cinthia Veronica Bardález López de CáceresDepartment of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.ORCID http://orcid.org/0000-0002-9032-2067
Hélen Kaline Farias BezerraOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil.ORCID http://orcid.org/0000-0002-5236-8988
João Paulo Gonçalves de PaivaOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil. joaopaulogoncalvesdepaiva@gmail.com.ORCID http://orcid.org/0000-0002-0079-2373
Brendo Vinícius Rodrigues LouredoOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil.ORCID http://orcid.org/0000-0002-5057-4008
Alan Roger Santos-SilvaOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil.ORCID http://orcid.org/0000-0003-2040-6617
Márcio Ajudarte LopesOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil.ORCID http://orcid.org/0000-0001-6677-0065
Pablo Agustin VargasOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil.ORCID http://orcid.org/0000-0003-1840-4911

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) Finance Code 001Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/ 01257-4
6 · The paper itself

Abstract

purposeThis study describes a large, well-documented case series of salivary gland polymorphous adenocarcinomas (PAC) from a single Brazilian center.

methodsDemographic data, clinical presentation, histopathological and immunohistochemical features from 26 cases of PAC were analyzed and discussed in detail.

resultsMost patients were females (n = 21), with a ratio of 1:4.2 (male: female) with a mean age of 58.8 years (ranging from 36 to 84 years). The most common clinical presentation was a fibrocollagenous, firm nodular lesion, with a mean size of 2.46 cm (ranging from 0.5 to 3 cm). Most lesions occurred on the palate (n = 16), followed by buccal mucosa (n = 3), upper lip (n = 3), buccal vestibule (n = 2) and alveolar ridge (n = 1). Histologically, various growth patterns were observed, including tubular, solid, cribriform, papillary, and cystic. Additionally, glomeruloid slit-like structures, mucous, and clear cells were noted. Surface papillary epithelial hyperplasia was observed in a few cases. Nine cases exhibited myxoid and collagenous areas, while two cases showed fusiform areas and another case demonstrated squamous differentiation. Clear cell predominance was noted in two cases, and peri- and intraneural invasion was seen in eight cases. Immunohistochemical analysis revealed positivity for S-100, p63 and CK7, and negativity for p40 in all cases. The Ki-67 proliferation index was markedly low in most cases, with a mean of 2.5%.

conclusionWe have provided a broad, detailed description of the clinical and microscopic features of PAC in a large, Brazilian cohort. These findings, in a resource-limited area, may be quite useful for establishing a proper diagnosis.

Indexed as

AdenocarcinomaSalivary Gland NeoplasmsAdultAgedAged, 80 and overBiomarkers, TumorBrazilFemaleHumansMaleMiddle AgedBiomarkers, TumorMinor salivary gland tumorsPolymorphous adenocarcinomaPolymorphous low-grade adenocarcinomaSalivary gland neoplasms

Identifiers

PMID38958847
PMCPMC11222357

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.