ArticleAdvances in therapy2024
Clinical Outcomes in Patients with CKD and Rapid or Non-rapid eGFR Decline: A Report from the DISCOVER CKD Retrospective Cohort.
Article in Advances in therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04034992 (An Observational Study Collecting Real-world Data on Patients With Chronic Kidney Disease to Assess), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Observational Study Collecting Real-world Data on Patients With Chronic Kidney Disease to Assess: Early Treatment Experience, Treatment Patterns, Treatment Effectiveness, Patient Outcomes and Patient Quality of Life Through Prospective and Retrospective Data Capture
Who cites it
13 citing papers in PubMed.
- Clinical Impact of RSV Vaccination in Hemodialysis Patients: Real-World Evidence on Hospitalization Risk and the Role of Chronic Lung Disease.Advances in respiratory medicine · 2026Article
- The Longitudinal Effect of APOL1 Risk Alleles on Sickle Cell Anemia-Associated Kidney Function.American journal of hematology · 2026Observational
- Machine learning-based prediction of a high-risk kidney function trajectory class after acute kidney injury.BMJ health & care informatics · 2026Article
- System Preparedness for Rising Kidney Replacement Therapy Demand: Late-Stage CKD Drives Costs, Healthcare Resource Utilisation and Environmental Impact in Switzerland.Advances in therapy · 2026Article
- Proteomic signatures of life's essential 8 and incident atrial fibrillation among individuals with chronic kidney disease.Nutrition & metabolism · 2026Article
- Observational
- Article
- Baseline and long-term frailty transitions and rapid estimated glomerular filtration rate decline: evidence from two large population-based studies.Renal failure · 2025Article
- Article
- Efficacy of screening with dipstick urinalysis in predicting renal function decline in healthy workers: a 10-year follow-up study.Clinical and experimental nephrology · 2025Article
- Stroke in patients with left ventricular assist device (LVAD): who is at risk?-a retrospective observational study at a tertiary care center.Frontiers in cardiovascular medicine · 2025Article
- IMPACT CKD: Holistic Disease Model Projecting 10-Year Population Burdens.Kidney international reports · 2024Article
- Association between changes of frailty status/frailty components status and rapid loss of kidney function in middle- aged and older populations.BMC nephrology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis analysis examined the baseline characteristics and clinical outcomes of patients with chronic kidney disease (CKD) and rapid or non-rapid estimated glomerular filtration rate (eGFR) decline, using retrospective data from DISCOVER CKD (ClinicalTrials.gov, NCT04034992).
methodsData (2008-2020) were extracted from UK Clinical Practice Research Datalink, US TriNetX, US Limited Claims and Electronic Health Record Dataset, and Japan Medical Data Vision. Patients with CKD (two consecutive eGFR measures < 75 mL/min/1.73 m
resultsAcross databases, rapid eGFR decline occurred in 13.7% of 804,237 eligible patients. Mean annual eGFR decline ranged between - 6.21 and - 6.86 mL/min/1.73 m
conclusionUnderstanding patient factors associated with rapid eGFR decline in patients with CKD may help identify individuals who would benefit from proactive management to minimize the risk of adverse outcomes.
trial registrationClinicalTrials.gov identifier, NCT04034992.
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