Evidence map›Paper›PMID 38958792›Full record

ArticleCell biology and toxicology2024

Zinc oxide nanoparticles induces cell death and consequently leading to incomplete neural tube closure through oxidative stress during embryogenesis.

Yu Yan, Wenyi Huang, Xiaoting Lu, Xianxian Chen, Yingyi Shan, Xin Luo, Yu Li, Xuesong Yang, Chun Li

Abstract read
In one paragraph

Article in Cell biology and toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. The expression of GSTP1 in the filum terminale of children with tethered cord syndrome.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yu Yan *School of Nursing, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Wenyi Huang *School of Nursing, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Xiaoting LuSchool of Nursing, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Xianxian ChenSchool of Nursing, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Yingyi ShanDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai, 200233, China.
Xin LuoDepartment of Urology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, 510060, China.
Yu LiSchool of Nursing, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. hlly@gzucm.edu.cn.
Xuesong YangDivision of Histology and Embryology, Medical College, Jinan University, Guangzhou, 510632, China. yang_xuesong@126.com.
Chun LiSchool of Nursing, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. hllc@gzucm.edu.cn.

Funding

2021 Guangdong Province Undergraduate College Teaching Quality and Teaching Reform Engineering Construction Project No.29Guangdong Basic and Applied Basic Research Foundation 2021A1515110232Guangdong Scientific Research Platform and Projects for the Higher-educational Institution 2022KTSCX025Research Project of Traditional Chinese Medicine Bureau of Guangdong 20211112the Science and Technology Program of Guangzhou 202201011394
6 · The paper itself

Abstract

The implementation of Zinc oxide nanoparticles (ZnO NPs) raises concerns regarding their potential toxic effects on human health. Although more and more researches have confirmed the toxic effects of ZnO NPs, limited attention has been given to their impact on the early embryonic nervous system. This study aimed to explore the impact of exposure to ZnO NPs on early neurogenesis and explore its underlying mechanisms. We conducted experiments here to confirm the hypothesis that exposure to ZnO NPs causes neural tube defects in early embryonic development. We first used mouse and chicken embryos to confirm that ZnO NPs and the Zn

Indexed as

Embryonic DevelopmentNeural TubeNeural Tube DefectsOxidative StressReactive Oxygen SpeciesZinc OxideAnimalsApoptosisAutophagyCell DeathCell Line, TumorChick EmbryoFemaleHumansMetal NanoparticlesMiceReactive Oxygen SpeciesZinc OxideApoptosisAutophagyFerroptosisNanoparticlesNeurogenesisOxidative stress

Identifiers

PMID38958792
PMCPMC11222284

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.