Evidence map›Paper›PMID 38958708›Full record

ArticleVirchows Archiv : an international journal of pathology2024

A morphological and immunohistochemical study of ductal carcinoma in situ, invasive breast carcinoma of no special type, and mucinous carcinoma of the breast in comparison with solid papillary carcinoma regarding neuroendocrine marker expression.

Yoshiro Otsuki, Yuki Asano, Tomonari Ikeya, Yuki Ishida, Shota Sezaki, Hiroshi Kobayashi

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yoshiro OtsukiDepartment of Pathology, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Chuo-Ku, Hamamatsu, 430-8558, Japan. otsuki@sis.seirei.or.jp.ORCID http://orcid.org/0000-0002-0568-3811
Yuki AsanoDepartment of Pathology, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Chuo-Ku, Hamamatsu, 430-8558, Japan.
Tomonari IkeyaDepartment of Clinical Laboratory, Seirei Hamamatsu General Hospital, Hamamatsu, Japan.
Yuki IshidaDepartment of Clinical Laboratory, Seirei Hamamatsu General Hospital, Hamamatsu, Japan.
Shota SezakiDepartment of Clinical Laboratory, Seirei Hamamatsu General Hospital, Hamamatsu, Japan.
Hiroshi KobayashiDepartment of Pathology, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Chuo-Ku, Hamamatsu, 430-8558, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The exact relationship between solid papillary carcinoma (SPC) and invasive breast carcinoma of no special type (IBC-NST) with neuroendocrine differentiation and SPC and mucinous carcinoma (MC) of the breast remains unclear. To clarify the relationship, we conducted a comparative study of morphological and neuroendocrine features between ductal carcinoma in situ (DCIS, 72 cases) and SPC in situ (35 cases), and IBC-NST (103 cases) and invasive SPC (92 cases). We also conducted the study between MC associated with and without SPC. Synaptophysin, chromogranin A, and INSM1 were employed for the immunohistochemical study. IBC-NST had occasionally a morphological similarity with invasive SPC. While 123 of 127 cases with SPC demonstrated diffuse staining with one or more of the neuroendocrine markers, the only one case of DCIS and none of IBC-NST showed it. Type B was observed in 16 of 18 cases of MC associated with SPC and in 13 of 33 cases of MC without it. All the cases of MC with SPC and 6 of 33 cases without it showed diffuse staining for at least one of the neuroendocrine markers. In conclusion, a careful distinction between invasive SPC and IBC-NST with neuroendocrine differentiation is required. We assume that SPC in situ is a potential candidate for precursor of IBC-NST with neuroendocrine differentiation. MC of the breast is suggested to have two pathogenetic pathways through SPC in situ or non-SPC in situ. SPC in situ is thought to be less common as a precursor of MC than non-SPC in situ.

Indexed as

Adenocarcinoma, MucinousBiomarkers, TumorBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingCarcinoma, PapillaryImmunohistochemistryAdultAgedAged, 80 and overCarcinoma, Ductal, BreastChromogranin AFemaleHumansMiddle AgedRepressor ProteinsSynaptophysinBiomarkers, TumorChromogranin AINSM1 protein, humanRepressor ProteinsSynaptophysinBreast cancerMucinous carcinomaNeuroendocrine carcinomaNeuroendocrine tumorSolid papillary carcinoma

Identifiers

PMID38958708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.