Article in Diabetologia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors.
Rebecca K DavidsonCenter for Diabetes & Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.
Wenting WuCenter for Diabetes & Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.
Sukrati KanojiaCenter for Diabetes & Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.
Rajani M GeorgeCenter for Diabetes & Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.
Kayla HuterCenter for Diabetes & Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.
Kassandra SandovalCenter for Diabetes & Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.
Meredith OsmulskiCenter for Diabetes & Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.
Nolan CaseyDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
Jason M SpaethCenter for Diabetes & Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA. jspaeth@iu.edu.
Funding
Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Sara K Quinney · 1999 to 2026
$59.3M
NIDDK Network Coordinating UnitU24DK097771 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Shuibing Chen, Jeffrey S. Grethe · 2013 to 2026
$20.9M
Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4M
Project-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7M
The role of Pdx1-recruited Chd4:NuRD complex in controlling mature #-cell functionR01DK129287 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Jason M Spaeth · 2022 to 2026
$2.0M
Pdx1 transcriptional activity and beta-cell function are dynamically modulated bycoregulators in physiological and pathophysiological conditions associated with Type 2 diabetesK01DK115633 · NIDDK · VANDERBILT UNIVERSITY · PI SPAETH, JASON M · 2018 to 2020
$438k
The Pdx1-recruited Swi/Snf chromatin remodeling complex regulates endocrine cell expansion and differentiation in vivoR03DK127129 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI SPAETH, JASON M · 2021 to 2022
$238k
Islet transcription factor activation: FoxPs are required for postnatal endocrine cell proliferation while Pdx1 recruited chromatin remodeling enzymes impact pancreas sizeF32DK104426 · NIDDK · VANDERBILT UNIVERSITY · PI SPAETH, JASON M · 2015 to 2015
$46k
Swi/Snf chromatin remodeling activity is required for islet cell development in vivoF31DK128918 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI DAVIDSON, REBECCA K · 2021 to 2021
$31k
Division of Cancer Prevention, National Cancer Institute CA082709Division of Diabetes, Endocrinology, and Metabolic Diseases DK097512Division of Diabetes, Endocrinology, and Metabolic Diseases DK097771Division of Diabetes, Endocrinology, and Metabolic Diseases DK106846Division of Diabetes, Endocrinology, and Metabolic Diseases DK115633Division of Diabetes, Endocrinology, and Metabolic Diseases DK127129Division of Diabetes, Endocrinology, and Metabolic Diseases DK128918Division of Diabetes, Endocrinology, and Metabolic Diseases DK129287NCI NIH HHS P30 CA082709NIDDK NIH HHS F31 DK128918NIDDK NIH HHS F32 DK104426NIDDK NIH HHS K01 DK115633NIDDK NIH HHS P30 DK097512NIDDK NIH HHS R01 DK129287NIDDK NIH HHS R03 DK127129NIDDK NIH HHS U24 DK097771NIDDK NIH HHS U54 DK106846
6 · The paper itself
Abstract
aims/hypothesisStrategies to augment functional beta cell mass include directed differentiation of stem cells towards a beta cell fate, which requires extensive knowledge of transcriptional programs governing endocrine progenitor cell differentiation in vivo. We aimed to study the contributions of the Brahma-related gene-1 (BRG1) and Brahma (BRM) ATPase subunits of the SWI/SNF chromatin remodelling complex to endocrine cell development.
methodsWe generated mice with endocrine progenitor-specific Neurog3-Cre BRG1 removal in the presence of heterozygous (Brg1
resultsBrg1 CONCLUSIONS/
interpretationLoss of BRG1 from developing endocrine progenitor cells has a severe postnatal impact on glucose homeostasis, and loss of both subunits impedes animal survival, with both groups exhibiting alterations in hormone transcripts embryonically. Taken together, these data highlight the critical role SWI/SNF plays in governing gene expression programs essential for endocrine cell development and expansion. DATA AVAILABILITY: Raw and processed data for scRNA-seq have been deposited into the NCBI Gene Expression Omnibus (GEO) database under the accession number GSE248369.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
The SWI/SNF chromatin remodelling complex regulates pancreatic endocrine cell expansion and differentiation in mice in vivo. · full record | OpenQuestion