ArticleThe journal of spinal cord medicine2025
Lesion characteristics are associated with bowel, bladder, and overall independence following cervical spinal cord injury.
Article in The journal of spinal cord medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Tissue bridges offer valuable insights into bladder and bowel outcomes in chronic cervical spinal cord injury.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Utilizing Predictive Analytics to Understand Neurogenic Bladder Symptom Score (NBSS) Variations in Adults With Acquired Spinal Cord Injury.Neurourology and urodynamics · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
CONTEXT/
objectiveThere is a growing global interest in quantifying spinal cord lesions and spared neural tissue using magnetic resonance imaging (MRI) in individuals with spinal cord injury (SCI). The primary objective of this study was to assess the relationships between spinal cord lesion characteristics assessed on MRI and bowel, bladder, and overall independence following SCI.
designRetrospective, exploratory study.
participants93 individuals with cervical SCI who were enrolled in a local United States Model Systems SCI database from 2010 to 2017.
methodsClinical and MRI data were obtained for potential participants, and MRIs of eligible participants were analyzed. Explanatory variables, captured on MRIs, included intramedullary lesion length (IMLL), midsagittal ventral tissue bridge width (VTBW), midsagittal dorsal tissue bridge width (DTBW), and axial damage ratio (ADR). OUTCOME MEASURES: Bowel and bladder management scale of the Functional Independence Measure (FIM) and FIM total motor score.
resultsWhen accounting for all four variables, only ADR was significantly associated with bowel independence (OR = 0.970, 95% CI: 0.942-0.997, P = 0.030), and both ADR and IMLL were strongly associated with bladder independence (OR = 0.967, 95% CI: 0.936-0.999, P = 0.046 and OR = 0.948, 95% CI: 0.919-0.978, P = 0.0007, respectively). 32% of the variation in overall independence scores were explained by all four predictive variables, but only ADR was significantly associated with overall independence after accounting for all other predictive variables (
conclusionsOur results suggest that the MRI-measured extent of spinal cord lesion may be predictive of bowel, bladder, and overall independence following cervical SCI.
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