Evidence map›Paper›PMID 38958134›Full record

ArticleJournal of the American Heart Association2024

Differences in Right Heart Function After Pulmonary Valve Replacement in Patients With Pulmonary Valve Stenosis Versus Tetralogy of Fallot.

Alexander C Egbe, C Charles Jain, Omar Abozied, Luke J Burchill, Ahmed Younis, Snigdha Karnakoti, Marwan H Ahmed, Heidi M Connolly

Abstract readComparative Study
In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexander C EgbeDepartment of Cardiovascular Medicine Mayo Clinic Rochester Rochester MN USA.ORCID 0000-0002-8810-3631
C Charles JainDepartment of Cardiovascular Medicine Mayo Clinic Rochester Rochester MN USA.ORCID 0000-0002-1116-8541
Omar AboziedDepartment of Cardiovascular Medicine Mayo Clinic Rochester Rochester MN USA.ORCID 0000-0001-6969-9815
Luke J BurchillDepartment of Cardiovascular Medicine Mayo Clinic Rochester Rochester MN USA.ORCID 0000-0001-9786-1840
Ahmed YounisDepartment of Cardiovascular Medicine Mayo Clinic Rochester Rochester MN USA.ORCID 0000-0001-9884-3302
Snigdha KarnakotiDepartment of Cardiovascular Medicine Mayo Clinic Rochester Rochester MN USA.ORCID 0000-0002-9415-5323
Marwan H AhmedDepartment of Cardiovascular Medicine Mayo Clinic Rochester Rochester MN USA.ORCID 0000-0002-9338-9961
Heidi M ConnollyDepartment of Cardiovascular Medicine Mayo Clinic Rochester Rochester MN USA.ORCID 0000-0003-0666-0344

Funding

Mechanisms of Clinical and Hemodynamic Response to Pulmonary Vasodilator Therapy in Fontan physiologyR01HL160761 · NHLBI · MAYO CLINIC ROCHESTER · PI Alexander Egbe · 2022 to 2026
$3.1M
Pathophysiologic Mechanism for Arrhythmias and Impaired Aerobic Capacity in Tetralogy of FallotR01HL158517 · NHLBI · MAYO CLINIC ROCHESTER · PI EGBE, ALEXANDER · 2021 to 2025
$2.9M
Clinical benefits and mechanism of action of angiotensin-II receptor blocker on Cardiovascular remodeling in patients with repaired coarctation of aortaR01HL162830 · NHLBI · MAYO CLINIC ROCHESTER · PI Alexander Egbe · 2023 to 2026
$2.7M
NHLBI NIH HHS R01 HL158517NHLBI NIH HHS R01 HL160761NHLBI NIH HHS R01 HL162830
6 · The paper itself

Abstract

backgroundThere are limited data about the impact of timing of pulmonary valve replacement (PVR) on right heart reverse remodeling in patients with pulmonary regurgitation following intervention for isolated pulmonary valve stenosis (PS). This study compared differences in postprocedural right heart reverse remodeling after early versus late PVR (defined as PVR before versus after attainment of the conservative consensus criteria proposed by Bokma et al, 2018) in patients with prior intervention for PS, using patients with tetralogy of Fallot as the reference group. METHOD AND

resultsRight atrial reservoir strain and right ventricular free wall strain was measured at baseline, 1 and 3 years after PVR. There were 114 patients with PS (early PVR, 87 [76%]; late PVR, 27 [24%]) and 291 patients with tetralogy of Fallot (early PVR, 197 [67%]; late PVR, 96 [33%]). The PS group had greater improvement in right atrial reservoir strain at 1 year (12%±4% versus 8%±4%;

conclusionsThese data suggest that patients with palliated PS presenting pulmonary regurgitation have a more benign clinical course, and hence delaying PVR in this population may be appropriate.

Indexed as

Heart Valve Prosthesis ImplantationPulmonary ValvePulmonary Valve StenosisTetralogy of FallotVentricular Function, RightVentricular RemodelingAdolescentAdultFemaleHumansMalePulmonary Valve InsufficiencyRetrospective StudiesTime FactorsTreatment OutcomeYoung Adultpulmonary valve replacementright heart remodelingrisk stratificationstrain imaging

Identifiers

PMID38958134
PMCPMC11292774

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.