Evidence map›Paper›PMID 38958117›Full record

SynthesisAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry.

Nicholas R Ray, Brian W Kunkle, Kara Hamilton-Nelson, Jiji T Kurup, Farid Rajabli, Min Qiao, Badri N Vardarajan, Mehmet I Cosacak, Caghan Kizil, Melissa Jean-Francois and 26 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Genetic and environmental risk factors for dementia in African adults: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Pooled it
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  3. Article
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  6. RBFOX1 association with age at onset of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  8. Local genetic correlation analysis of Alzheimer's disease and stroke implicatesmedRxiv : the preprint server for health sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Nicholas R RayTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.
Brian W KunkleThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
Kara Hamilton-NelsonThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
Jiji T KurupTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.
Farid RajabliThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
Min QiaoTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.
Badri N VardarajanTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.
Mehmet I CosacakGerman Center for Neurodegenerative Diseases, Dresden, Germany.
Caghan KizilTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.
Melissa Jean-FrancoisThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
Michael CuccaroThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
Dolly Reyes-DumeyerTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.
Laura CantwellPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Amanda KuzmaPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Jeffery M VanceThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
Sujuan GaoDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Hugh C HendrieDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Olusegun BaiyewuCollege of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Adesola OgunniyiCollege of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Rufus O AkinyemiCollege of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Alzheimer's Disease Genetics Consortium
Wan-Ping LeePenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Eden R MartinThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
Li-San WangPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Gary W BeechamThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
William S BushDepartment of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Biomedical Research, Cleveland, Ohio, USA.
Wanying XuDepartment of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Biomedical Research, Cleveland, Ohio, USA.
Fulai JinDepartment of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Biomedical Research, Cleveland, Ohio, USA.
Liyong WangThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
Lindsay A FarrerDepartment of Medicine, Biomedical Genetics Section, Boston University School of Medicine, Boston, Massachusetts, USA.
Jonathan L HainesDepartment of Population and Quantitative Health Sciences and Cleveland Institute for Computational Biology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Goldie S ByrdMaya Angelou Center for Health Equity, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Gerard D SchellenbergPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Richard MayeuxTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.
Margaret A Pericak-VanceThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
Christiane ReitzTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
TRIAL OF VALPROATE TO ATTENUATE THE PROGRESSION OF ADU01AG010483 · NIA · UNIVERSITY OF ROCHESTER · PI AISEN, PAUL S. · 1991 to 2012
$116.2M
NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5M
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Alzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4M
THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI GRABOWSKI, THOMAS J. · 1985 to 2019
$57.2M
VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALASKO, DOUGLAS R · 1985 to 2018
$55.4M
Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP)U19AG074865 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GOLDIE S. BYRD, William S Bush · 2022 to 2026
$55.3M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5M
AbbVieAlzheimer's Association IIRG-05-14147Alzheimer's Association IIRG-08-89720Alzheimer's Drug Discovery FoundationAlzheimer's Research TrustAraclon BiotechBioClinica, Inc.BiogenBiomedical Laboratory Research ProgramBoston University R01AG33193Boston University U01 AG10483BRACEBrain Net EuropeBrightFocus Foundation A2111048BrightFocus Foundation MP-VBristol-Myers Squibb CompanyCanadian Institute of Health ResearchCereSpir, Inc.DeNDRoNDepartment of Defense W81XWH-12-2-0012Duke University AG05128Eisai Inc.Elan Pharmaceuticals, Inc.Eli Lilly and CompanyEmory University AG025688EuroImmun; F. Hoffmann-La Roche LtdFujirebioGE HealthcareGenentech, Inc.Glaxo Smith KlineGroup Health Research Institute UO1 AG006781Group Health Research Institute UO1 HG004610Group Health Research Institute UO1 HG006375Hersenstichting Nederland Breinbrekend WerkHigher Education Funding Council for EnglandHoward Hughes Medical InstituteIllinois Department of Public HealthIndiana University P30 AG10133Internationale Stiching Alzheimer OnderzoekInternational Parkinson FondsIXICO Ltd.Janssen Alzheimer Immunotherapy Research & Development, LLC.Johnson & Johnson Pharmaceutical Research & Development LLC.Kronos ScienceLumosityLundbeckMedical Research CouncilMerck & Co., Inc.Meso Scale Diagnostics, LLC.National Cell Repository for Alzheimer's Disease (NCRAD) U24 AG21886National Institutes of Health, National Institute on Aging (NIH-NIA) ADGCNCI NIH HHS R01 CA129769NCI NIH HHS R01 CA267872NCRR NIH HHS KL2 RR024151NCRR NIH HHS UL1 RR029893NeuroRx ResearchNeurotrack TechnologiesNewcastle UniversityNew York University 1R01AG035137New York University 1RC2AG036502New York University 5R01AG012101New York University 5R01AG013616New York University 5R01AG022374New York University P30 AG08051NHGRI NIH HHS R01 HG009658NHGRI NIH HHS R01 HG012384NHGRI NIH HHS U01 HG004610NHGRI NIH HHS U01 HG006375NHGRI NIH HHS U01 HG008657NHS trustsNIA FBS (Columbia University) R01AG041797NIA FBS (Columbia University) U24 AG026390NIA NIH HHS AG041232NIA NIH HHS AG052410NIA NIH HHS P01 AG002219NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG010491NIA NIH HHS P01 AG019724NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG008017NIA NIH HHS P30 AG008051NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG012300NIA NIH HHS P30 AG013846NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG028377NIA NIH HHS P30 AG028383NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066462NIA NIH HHS P30 AG066518NIA NIH HHS P30 AG072976NIA NIH HHS P30 AG072980NIA NIH HHS P30AG10161NIA NIH HHS P50 AG005128NIA NIH HHS P50 AG005131NIA NIH HHS P50 AG005133NIA NIH HHS P50 AG005134NIA NIH HHS P50 AG005136NIA NIH HHS P50 AG005138NIA NIH HHS P50 AG005142NIA NIH HHS P50 AG005144NIA NIH HHS P50 AG005146NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG008671NIA NIH HHS P50 AG008702NIA NIH HHS P50 AG016570NIA NIH HHS P50 AG016573NIA NIH HHS P50 AG016574NIA NIH HHS P50 AG016582NIA NIH HHS P50 AG023501NIA NIH HHS P50 AG025688NIA NIH HHS P50 AG033514NIA NIH HHS R01 AG009029NIA NIH HHS R01 AG009956NIA NIH HHS R01 AG012101NIA NIH HHS R01 AG013616NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017173NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG019085NIA NIH HHS R01 AG019757NIA NIH HHS R01 AG020688NIA NIH HHS R01 AG021547NIA NIH HHS R01 AG022018NIA NIH HHS R01 AG022374NIA NIH HHS R01 AG025259NIA NIH HHS R01 AG026390NIA NIH HHS R01 AG026916NIA NIH HHS R01 AG027944NIA NIH HHS R01 AG028786NIA NIH HHS R01 AG030146NIA NIH HHS R01 AG030653NIA NIH HHS R01 AG031581NIA NIH HHS R01 AG032990NIA NIH HHS R01 AG033193NIA NIH HHS R01 AG035137NIA NIH HHS R01 AG036042NIA NIH HHS R01 AG036836NIA NIH HHS R01 AG037212NIA NIH HHS R01 AG041232NIA NIH HHS R01 AG041718NIA NIH HHS R01 AG041797NIA NIH HHS R01 AG042437NIA NIH HHS R01 AG048015NIA NIH HHS R01 AG048927NIA NIH HHS R01 AG064614NIA NIH HHS R01 AG072474NIA NIH HHS R01 AG072547NIA NIH HHS R01AG15819NIA NIH HHS R01AG17917NIA NIH HHS R01AG30146NIA NIH HHS R01AG36042NIA NIH HHS R01AG36836NIA NIH HHS R01AG48015NIA NIH HHS R37 AG015473NIA NIH HHS RC2 AG036502NIA NIH HHS RC2 AG036528NIA NIH HHS RC2 AG036547NIA NIH HHS RC2AG036547NIA NIH HHS RC2 AG036650NIA NIH HHS RF1 AG057473NIA NIH HHS RF1 AG059018NIA NIH HHS RF1AG57473NIA NIH HHS U01 AG006781NIA NIH HHS U01 AG010483NIA NIH HHS U01 AG016976NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG032984NIA NIH HHS U01 AG046152NIA NIH HHS U01 AG046161NIA NIH HHS U01 AG052410NIA NIH HHS U01 AG057659NIA NIH HHS U01 AG058654NIA NIH HHS U01 AG061356NIA NIH HHS U01 AG062943NIA NIH HHS U01 AG072579NIA NIH HHS U01AG32984NIA NIH HHS U01AG46152NIA NIH HHS U01AG46161NIA NIH HHS U01AG61356NIA NIH HHS U19 AG074865NIA NIH HHS U24 AG021886NIA NIH HHS U24 AG026395NIA NIH HHS U24 AG041689NIA NIH HHS U24 AG056270NIA NIH HHS U54 AG052427NIBIB NIH HHSNIDDK NIH HHS R01 DK131437NIH HHS P30AG066462NIH HHS R01AG048927NIH HHS R01AG064614NIH HHS R01AG072547NIH HHS RF1AG059018NIH HHS U01 AG024904NIH HHS U01AG057659NIH HHS U01AG058654NIH HHS U01AG062943NIH HHS U01AG072579NIH HHS U19AG074865NIH HHS U24AG056270NIMHD NIH HHS P20 MD000546NIMH NIH HHS P50 MH060451NIMH NIH HHS R01 MH080295NINDS NIH HHS NIMH MH60451NINDS NIH HHS # NS39764NINDS NIH HHS P50 NS039764NINDS NIH HHS R01 NS059873NINDS NIH HHS UG3 NS132061North Bristol NHS Trust Research and Innovation DepartmentNorth Carolina A&T University R01 AG28786-01A1Novartis Pharmaceuticals CorporationOffice of Research and DevelopmentPfizer Inc.Piramal ImagingRush University R01 AG01101Rush University R01 AG15819Rush University R01 AG17917Rush University R01 AG22018ServierStichting MS ResearchTakeda Pharmaceutical CompanyTransition TherapeuticsTranslational Genomics Research InstituteUniversity of Kentucky AG05144University of Miami AG010491University of Miami AG019757University of Miami AG021547University of Miami AG027944University of Pennsylvania U24-AG041689University of Pittsburgh AG02365University of Pittsburgh AG030653University of Pittsburgh AG041718University of Pittsburgh AG07562University of Washington P01 AG03991US Department of Veterans Affairs AdministrationWellcome Trust
6 · The paper itself

Abstract

introductionDespite a two-fold risk, individuals of African ancestry have been underrepresented in Alzheimer's disease (AD) genomics efforts.

methodsGenome-wide association studies (GWAS) of 2,903 AD cases and 6,265 controls of African ancestry. Within-dataset results were meta-analyzed, followed by functional genomics analyses.

resultsA novel AD-risk locus was identified in MPDZ on chromosome (chr) 9p23 (rs141610415, MAF = 0.002, p = 3.68×10 DISCUSSION: These analyses identified novel AD-associated loci in individuals of African ancestry and suggest that degree of African ancestry modulates some associations. Increased sample sets covering as much African genetic diversity as possible will be critical to identify additional loci and deconvolute local genetic ancestry effects. HIGHLIGHTS: Genetic ancestry significantly impacts risk of Alzheimer's Disease (AD). Although individuals of African ancestry are twice as likely to develop AD, they are vastly underrepresented in AD genomics studies. The Alzheimer's Disease Genetics Consortium has previously identified 16 common and rare genetic loci associated with AD in African American individuals. The current analyses significantly expand this effort by increasing the sample size and extending ancestral diversity by including populations from continental Africa. Single variant meta-analysis identified a novel genome-wide significant AD-risk locus in individuals of African ancestry at the MPDZ gene, and 11 additional novel loci with suggestive genome-wide significance at p < 9×10-7. Comparison of African American datasets with samples of higher degree of African ancestry demonstrated differing patterns of association and linkage disequilibrium at one of these loci, suggesting that degree and/or geographic origin of African ancestry modulates the effect at this locus. These findings illustrate the importance of increasing number and ancestral diversity of African ancestry samples in AD genomics studies to fully disentangle the genetic architecture underlying AD, and yield more effective ancestry-informed genetic screening tools and therapeutic interventions.

Indexed as

Alzheimer DiseaseBlack PeopleGenetic Predisposition to DiseaseGenome-Wide Association StudyLinkage DisequilibriumPolymorphism, Single NucleotideAgedFemaleHumansMaleAfrican AmericansAfrican genome PanelAlzheimer's diseasegenome‐wide association study

Identifiers

PMID38958117
PMCPMC11350055

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