Comment on Callado et al: "Syphilis Treatment: Systematic Review and Meta-analysis Investigating Nonpenicillin Therapeutic Strategies".

Chase A Cannon, Tim W Menza, Tara B Reid, Nicole A P Lieberman, Lorenzo Giacani, Alexander L Greninger

Abstract read

In one paragraph

Article in Open forum infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Expanding Horizons in Syphilis Treatment: Challenges, Advances, and Opportunities for Alternative Antibiotics.Current HIV/AIDS reports · 2025
Review
Too Late to Treat: Missed Antenatal Syphilis Screening and a Fatal Neonatal Outcome - A Case Report.International medical case reports journal · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chase A CannonDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-2962-754X

Tim W MenzaDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.

Tara B ReidDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.

Nicole A P LiebermanDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.

Lorenzo GiacaniDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0003-3889-7274

Alexander L GreningerDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-7443-0527

Funding

VENEREAL DISEASET32AI007140 · NIAID · UNIVERSITY OF WASHINGTON · PI Julia Cook Dombrowski · 1985 to 2026

$19.4M

NIAID NIH HHS T32 AI007140

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID38957685

DOI10.1093/ofid/ofae324

PMCPMC11218762

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.