Evidence map›Paper›PMID 38957437›Full record

ArticleClinical & translational immunology2024

Metabolic requirements of CD160 expressing memory-like NK cells in Gram-negative bacterial infection.

Anucha Preechanukul, Natnaree Saiprom, Kitilak Rochaikun, Boonthanom Moonmueangsan, Rungnapa Phunpang, Orawan Ottiwet, Yuphin Kongphrai, Soonthon Wapee, Rachan Janon, Susanna Dunachie and 2 more

Abstract read
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Article in Clinical & translational immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anucha PreechanukulDepartment of Microbiology and Immunology, Faculty of Tropical Medicine Mahidol University Bangkok Thailand.
Natnaree SaipromDepartment of Microbiology and Immunology, Faculty of Tropical Medicine Mahidol University Bangkok Thailand.
Kitilak RochaikunDepartment of Microbiology and Immunology, Faculty of Tropical Medicine Mahidol University Bangkok Thailand.
Boonthanom MoonmueangsanDepartment of Microbiology and Immunology, Faculty of Tropical Medicine Mahidol University Bangkok Thailand.
Rungnapa PhunpangDepartment of Microbiology and Immunology, Faculty of Tropical Medicine Mahidol University Bangkok Thailand.
Orawan OttiwetDepartment of Medical Technology and Clinical Pathology Mukdahan Hospital Mukdahan Thailand.
Yuphin KongphraiDepartment of Medical Technology and Clinical Pathology Mukdahan Hospital Mukdahan Thailand.
Soonthon WapeeDepartment of Medical Technology and Clinical Pathology Mukdahan Hospital Mukdahan Thailand.
Rachan JanonDepartment of Medicine Mukdahan Hospital Mukdahan Thailand.
Susanna DunachieMahidol-Oxford Tropical Medicine Research Unit Mahidol University Bangkok Thailand.
Barbara KronsteinerPeter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine University of Oxford Oxford UK.
Narisara ChantratitaDepartment of Microbiology and Immunology, Faculty of Tropical Medicine Mahidol University Bangkok Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Unique metabolic requirements accompany the development and functional fates of immune cells. How cellular metabolism is important in natural killer (NK) cells and their memory-like differentiation in bacterial infections remains elusive. Methods: Here, we utilise our established NK cell memory assay to investigate the metabolic requirement for memory-like NK cell formation and function in response to the Gram-negative intracellular bacteria Results: We demonstrate that CD160 Conclusion: This study reveals the link between metabolism and cellular function of memory-like NK cells, which can be exploited for vaccine design and for monitoring protection against Gram-negative bacterial infection.

Indexed as

Gram‐negative bacterial infectionimmunometabolismmelioidosisNK cellNK cell memory

Identifiers

PMID38957437
PMCPMC11218174

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