Evidence map›Paper›PMID 38957326›Full record

ArticleFrontiers in oncology2024

Case report: Microsatellite instability determination is not always black and white in Lynch syndrome diagnosis.

Julieta E Rodriguez, Damien Vasseur, Mohamed Amine Bani, Odile Cabaret, Sophie Cotteret, Martine Muleris, Veronica Golbarg, David Malka, Thomas Pudlarz, Olivier Caron and 1 more

Abstract readCase Reports
In one paragraph

Article in Frontiers in oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Julieta E RodriguezDrug Development Department, Gustave Roussy Cancer Campus, Villejuif, France.
Damien VasseurMedical Biology and Pathology Department, Gustave Roussy Cancer Campus, Villejuif, France.
Mohamed Amine BaniMedical Biology and Pathology Department, Gustave Roussy Cancer Campus, Villejuif, France.
Odile CabaretMedical Biology and Pathology Department, Gustave Roussy Cancer Campus, Villejuif, France.
Sophie CotteretBiology and Genetics Department, Centre Eugène Marquis, Rennes, France.
Martine MulerisDepartment of Genetics, Hôpital Pitié-Salpêtrière, Assistance Publique - Hôpitaux de Paris (AP-HP), Sorbonne Université, Paris, France.
Veronica GolbargMedical Oncology Department, Gustave Roussy Cancer Campus, Villejuif, France.
David MalkaGastroenterology and Hepatology Department, Institut Mutualiste Montsouris, Paris, France.
Thomas PudlarzMedical Oncology Department, Gustave Roussy Cancer Campus, Villejuif, France.
Olivier CaronMedical Oncology Department, Gustave Roussy Cancer Campus, Villejuif, France.
Cristina SmolenschiDrug Development Department, Gustave Roussy Cancer Campus, Villejuif, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Microsatellite instability (MSI) is a genetic marker that is useful in the detection and treatment of Lynch syndrome (Sd). Although conventional techniques such as immunohistochemistry (IHC) and polymerase chain reaction (PCR) are the standards for MSI detection, the advent of next-generation sequencing (NGS) has offered new possibilities, especially with circulating DNA. Case report: We present the case of a 26-year-old patient with Lynch Sd and a Conclusion: This case emphasizes the importance of comprehensive molecular profiling and strong interdisciplinary collaborations, especially in cases with ambiguous MSI results.

Indexed as

case reportcirculating DNAcolorectal cancerdiscordant MSInext-generation sequencing

Identifiers

PMID38957326
PMCPMC11217479

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.