Evidence map›Paper›PMID 38957135›Full record

ReviewInsect molecular biology2025

Recent advances in understanding of the mechanisms of RNA interference in insects.

Jinmo Koo, Subba Reddy Palli

Abstract readReview
In one paragraph

Review in Insect molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Antagonism of RNA silencing in the yellow fever mosquito,Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
  9. Biocompatible Copolymerized Gold Nanoclusters: Anti-Biomimetics (Basel, Switzerland) · 2025
    Article
  10. Disruption ofVirulence · 2025
    Article
  11. Article
  12. Review
  13. Article
  14. Expression ofLife (Basel, Switzerland) · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jinmo KooDepartment of Entomology, Gatton-Martin College of Agriculture, University of Kentucky, Lexington, Kentucky, USA.
Subba Reddy PalliDepartment of Entomology, Gatton-Martin College of Agriculture, University of Kentucky, Lexington, Kentucky, USA.ORCID https://orcid.org/0000-0002-0873-3247

Funding

Molecular Analysis of Juvenile Hormone ActionR01GM070559 · NIGMS · UNIVERSITY OF KENTUCKY · PI PALLI, SUBBA R · 2005 to 2024
$4.1M
RNAi methods for Zika virus vector controlR21AI131427 · NIAID · UNIVERSITY OF KENTUCKY · PI PALLI, SUBBA R · 2017 to 2018
$385k
NIAID NIH HHS R21 AI131427NIGMS NIH HHS R01 GM070559NIH HHS 1R21AI131427-01NIH HHS GM070559-15University Cooperative Research Centers, the Center for Arthropod Management Technologies IIP-1821936USDA/NIFA 2019-67013-29351USDA/NIFA 2351177000
6 · The paper itself

Abstract

We highlight the recent 5 years of research that contributed to our understanding of the mechanisms of RNA interference (RNAi) in insects. Since its first discovery, RNAi has contributed enormously as a reverse genetic tool for functional genomic studies. RNAi is also being used in therapeutics, as well as agricultural crop and livestock production and protection. Yet, for the wider application of RNAi, improvement of its potency and delivery technologies is needed. A mechanistic understanding of every step of RNAi, from cellular uptake of RNAi trigger molecules to targeted mRNA degradation, is key for developing an efficient strategy to improve RNAi technology. Insects provide an excellent model for studying the mechanism of RNAi due to species-specific variations in RNAi efficiency. This allows us to perform comparative studies in insect species with different RNAi sensitivity. Understanding the mechanisms of RNAi in different insects can lead to the development of better strategies to improve RNAi and its application to manage agriculturally and medically important insects.

Indexed as

InsectaRNA InterferenceAnimalsRNA, Small InterferingRNA, Small InterferingdsRNAinsectsmechanismsRNAi

Identifiers

PMID38957135
PMCPMC11695441

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.