Evidence map›Paper›PMID 38956909›Full record

ArticleCurrent drug delivery2025

Samar Vihal, Swati Pundir, Charul Rathore, Uma Ranjan Lal, Gaurav Gupta, Sachin Kumar Singh, Kamal Dua, Dinesh Kumar Chellappan, Poonam Negi

Abstract read
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In one paragraph

Article in Current drug delivery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Samar VihalSchool of Pharmaceutical Sciences, Shoolini University, PO Box 9, Solan, Himachal Pradesh 173229, India.
Swati PundirSchool of Pharmaceutical Sciences, Shoolini University, PO Box 9, Solan, Himachal Pradesh 173229, India.
Charul RathoreDepartment of Pharma Sciences, Chandigarh University, Mohali, Punjab 140413, India.
Uma Ranjan LalAyurvet Limited, Katha, Baddi, Himachal Pradesh 173205, India.
Gaurav GuptaSchool of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur, 302017, India.
Sachin Kumar SinghSchool of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T Road, Phagwara, Punjab, India.
Kamal DuaDiscipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia.
Dinesh Kumar ChellappanDepartment of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Malaysia.
Poonam NegiSchool of Pharmaceutical Sciences, Shoolini University, PO Box 9, Solan, Himachal Pradesh 173229, India.ORCID 0000-0003-3722-991X

Funding

School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, India 1991701004
6 · The paper itself

Abstract

backgroundThe therapeutic effect of NS oil in mild to moderate psoriasis is limited owing to low play load of thymoquinone (<15 %w/w), irritation, dripping, low viscosity and thus, less contact time on the lesions.

aimsThis study aimed at developing and characterizing the ethanolic vesicular hydrogel system of Nigella sativa (NS) oil (NS EV hydrogel) for the enhancement of anti-psoriatic activity.

objectiveThe objective of this study was to develop NS EV hydrogel and evaluate its anti-psoriatic activity.

methodsThe identification and quantification of TQ content in different NS seed extracts and marketed oil were measured by an HPTLC method using n-hexane and ethyl acetate as solvent systems. Preparation of ethanolic vesicles (EVs) was performed by solvent injection method, while its antipsoriatic activity was evaluated employing an Imiquad (IMQ)-induced plaque psoriasis animal model.

resultsA compact HPTLC band was obtained for TQ at an R

conclusionIt may be concluded from the findings that NS-loaded EV gel was as good as betamethasone cream but more efficacious than the other treatments.

Indexed as

ImiquimodPlant OilsPsoriasisRheologyAnimalsCarumEthanolGelsHydrogelsMaleMiceNigella sativacaraway essential oilcaraway oilEthanolGelsHydrogelsImiquimodPlant Oilsethanolic vesiclesimiquadmicromeritics.Nigella sativapsoriasisthymoquinone

Identifiers

PMID38956909

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.